ICCAS OpenIR
Covalently Attached, Silver-Doped Poly(vinyl alcohol) Hydrogel Films on Poly(L-lactic acid)
Zan, Xingjie1; Kozlov, Mikhail2; McCarthy, Thomas J.2; Su, Zhaohui1
2010-04-01
Source PublicationBIOMACROMOLECULES
ISSN1525-7797
Volume11Issue:4Pages:1082-1088
AbstractCovalently attached, soft poly(vinyl alcohol) (PVA) hydrogel films containing silver particles were prepared on solid biodegradable poly(L-lactic acid) (PLLA) samples by a multistep procedure involving oxygen plasma treatment, UV-initiated graft polymerization, and chemical grafting methods. The modification steps were followed and verified using attenuated total reflection infrared spectroscopy and X-ray photoelectron spectroscopy. 2-Hydroxyethyl methacrylate (HEMA) was graft polymerized from the surface of oxygen plasma-treated PLLA film samples and the alcohol functionality in the grafted polyHEMA chains was oxidized using pyridinium dichromate to obtain an aldehyde-rich surface. PVA was then grafted onto this surface using acid catalysis (acetal formation). The "freeze/thaw method" was used to form a PVA hydrogel layer that incorporated the covalently grafted PVA chains in the physically cross-linked gel. This composite film (PLLA-PVA(gel)) was doped with silver ions, which were reduced to silver using NaBH(4). Scanning electron microscopy of cross sections of PLLA-PVA(gel) indicates robust attachment of the PVA hydrogel layer to the PLLA film. PLLA-PVA(gel/Ag(0)) film samples exhibit both antibacterial and reduced cell adhesion properties due to the antibacterial properties of silver nanoparticles and high water content, respectively. This method provides a route to mechanically sound biodegradable materials with tunable soft material surface properties. Potential applications in tissue engineering and biomedical devices are envisioned.
DOI10.1021/bm100048q
Indexed BySCI
Language英语
WOS IDWOS:000276557300033
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:52[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/69818
Collection中国科学院化学研究所
Corresponding AuthorSu, Zhaohui
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Univ Massachusetts, Dept Polymer Sci & Engn, Amherst, MA 01003 USA
Recommended Citation
GB/T 7714
Zan, Xingjie,Kozlov, Mikhail,McCarthy, Thomas J.,et al. Covalently Attached, Silver-Doped Poly(vinyl alcohol) Hydrogel Films on Poly(L-lactic acid)[J]. BIOMACROMOLECULES,2010,11(4):1082-1088.
APA Zan, Xingjie,Kozlov, Mikhail,McCarthy, Thomas J.,&Su, Zhaohui.(2010).Covalently Attached, Silver-Doped Poly(vinyl alcohol) Hydrogel Films on Poly(L-lactic acid).BIOMACROMOLECULES,11(4),1082-1088.
MLA Zan, Xingjie,et al."Covalently Attached, Silver-Doped Poly(vinyl alcohol) Hydrogel Films on Poly(L-lactic acid)".BIOMACROMOLECULES 11.4(2010):1082-1088.
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