ICCAS OpenIR
Advances in Biodistribution Study and Tracing Methodology of Carbon Nanotubes
Liu, Jia-Hui1; Yang, Sheng-Tao1; Wang, Haifang1,2; Liu, Yuanfang1,2
2010-12-01
Source PublicationJOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY
ISSN1533-4880
Volume10Issue:12Pages:8469-8481
AbstractRecent advances in applications of carbon nanotubes (CNTs) require thorough investigation of their in vivo behavior and fate. Biodistribution, as fundamental information for pharmacology and toxicology, should be intensively and systematically studied to accelerate the related researches. In this review, we summarized currently applied methodology in the study of CNTs biodistribution and the achieved biodistribution data. However, the currently used methods, including isotopic labeling, Raman spectroscopy and TEM investigation, can hardly reach a perfect balance of convenience and reliability. We compared the advantage and disadvantage of each method to show diversified choices for different purposes. Based on these techniques, available data suggest that CNTs have a general trend of high reticuloendothelial system (RES) uptake. But their distribution can be dramatically regulated by functionalization of the CNT surface with various molecules. For future biodistribution studies, developing convenient and reliable methods is highly required, and key parameters determining the behavior and fate of CNTs in vivo should be further explored and elicited.
KeywordCarbon Nanotube Biodistribution Tracing Methodology In Vivo
DOI10.1166/jnn.2010.2689
Indexed BySCI ; ISTP
Language英语
WOS IDWOS:000283621400083
PublisherAMER SCIENTIFIC PUBLISHERS
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/69558
Collection中国科学院化学研究所
Corresponding AuthorWang, Haifang
Affiliation1.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
2.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China
Recommended Citation
GB/T 7714
Liu, Jia-Hui,Yang, Sheng-Tao,Wang, Haifang,et al. Advances in Biodistribution Study and Tracing Methodology of Carbon Nanotubes[J]. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,2010,10(12):8469-8481.
APA Liu, Jia-Hui,Yang, Sheng-Tao,Wang, Haifang,&Liu, Yuanfang.(2010).Advances in Biodistribution Study and Tracing Methodology of Carbon Nanotubes.JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY,10(12),8469-8481.
MLA Liu, Jia-Hui,et al."Advances in Biodistribution Study and Tracing Methodology of Carbon Nanotubes".JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 10.12(2010):8469-8481.
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