ICCAS OpenIR
Lipid coated mesoporous silica nanoparticles as photosensitive drug carriers
Yang, Yang1; Song, Weixing1; Wang, Anhe2; Zhu, Pengli2; Fei, Jinbo2; Li, Junbai1,2
2010
Source PublicationPHYSICAL CHEMISTRY CHEMICAL PHYSICS
ISSN1463-9076
Volume12Issue:17Pages:4418-4422
AbstractThis paper presents a strategy for the biofunctionalization of novel photosensitizer carriers, mesoporous silica nanoparticles (MSNs). After being calcined and absorbed with photosensitizers ( hypocrellin B, HB), MSNs can be coated with a lipid layer. Transmission electron microscopy (TEM) and confocal laser scanning microscopy (CLSM) results proved that HB molecules can be loaded into MSN porous and lipid can coated on the surface of the nanoparticles. When co-cultured with cancer cells (MCF-7), MSNs can transport HB molecules into cells and present low cytotoxicity. With the introduction of a lipid layer, the efficiency of MSN uptake by cells can be improved. These intracellular HB-loaded MSN materials also present cytotoxicity to MCF-7 cells after light irradiation which indicates the materials can be used as good photosensitizer carriers in photodynamic therapy.
DOI10.1039/b924370d
Indexed BySCI
Language英语
WOS IDWOS:000276896000021
PublisherROYAL SOC CHEMISTRY
Citation statistics
Cited Times:85[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/69388
Collection中国科学院化学研究所
Corresponding AuthorLi, Junbai
Affiliation1.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
2.Chinese Acad Sci, BNLMS, Key Lab Colloid & Interface Sci, Inst Chem, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Yang, Yang,Song, Weixing,Wang, Anhe,et al. Lipid coated mesoporous silica nanoparticles as photosensitive drug carriers[J]. PHYSICAL CHEMISTRY CHEMICAL PHYSICS,2010,12(17):4418-4422.
APA Yang, Yang,Song, Weixing,Wang, Anhe,Zhu, Pengli,Fei, Jinbo,&Li, Junbai.(2010).Lipid coated mesoporous silica nanoparticles as photosensitive drug carriers.PHYSICAL CHEMISTRY CHEMICAL PHYSICS,12(17),4418-4422.
MLA Yang, Yang,et al."Lipid coated mesoporous silica nanoparticles as photosensitive drug carriers".PHYSICAL CHEMISTRY CHEMICAL PHYSICS 12.17(2010):4418-4422.
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