ICCAS OpenIR
Antipolyelectrolyte swelling of amphiphilic hydroxypropyl methylcellulose phthalate gels
Wang, Min1; Xu, Ling1,2; Li, Cancan1; Yue, Zhiying1; Zhai, Maolin1; Li, Jiuqiang1
2010-03-05
Source PublicationCOLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS
ISSN0927-7757
Volume356Issue:1-3Pages:89-96
AbstractHydroxypropyl methylcellulose phthalate (HPMCP) gel was synthesized from the sodium form of HPMCP by radiation-induced crosslinking, followed by converting the phthalate groups on HPMCP to non-ionic forms via ion exchange. The non-ionic H-type gels showed different phase transition behaviors from Na-type gels. Significant anti polyelectrolyte swelling behavior of this amphiphilic gel was observed in various aqueous salt solutions, comparing with the polyelectrolyte swelling behavior of ionic HPMCP gels. After immersed in aqueous salt solution, the morphology of H-type HPMCP gels changed from heterogeneous structure to homogeneous structure. The swelling behavior of the gels in several circumstances with potential applications. for instance, solutions with different temperature and pH, surfactants. and typical drug models, were investigated. H-type HPMCP gels showed similar temperature and pH-stimuli responses to that of Na-type HPMCP gels. Furthermore, H-type HPMCP gels showed different swelling behaviors in cationic surfactant (C(12)TAB) and anionic surfactant (SDS) solutions. The investigations regarding drug embedment and release of this amphiphilic gel in inorganic salt and BSA solutions revealed that the embedment amount and release ratio were both high due to the improved swelling ability in saline condition of H-type HPMCP gels. (C) 2010 Elsevier B.V. All rights reserved.
KeywordHydroxypropylmethylcellulose Phthalate Gel Amphiphilic Antipolyelectrolyte Effect Drug Release
DOI10.1016/j.colsurfa.2009.12.033
Indexed BySCI
Language英语
WOS IDWOS:000275351400015
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/69358
Collection中国科学院化学研究所
Corresponding AuthorXu, Ling
Affiliation1.Peking Univ, Beijing Natl Lab Mol Sci, Dept Appl Chem, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
2.Peking Univ, Coll Engn, Dept Energy & Resources Engn, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Wang, Min,Xu, Ling,Li, Cancan,et al. Antipolyelectrolyte swelling of amphiphilic hydroxypropyl methylcellulose phthalate gels[J]. COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,2010,356(1-3):89-96.
APA Wang, Min,Xu, Ling,Li, Cancan,Yue, Zhiying,Zhai, Maolin,&Li, Jiuqiang.(2010).Antipolyelectrolyte swelling of amphiphilic hydroxypropyl methylcellulose phthalate gels.COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS,356(1-3),89-96.
MLA Wang, Min,et al."Antipolyelectrolyte swelling of amphiphilic hydroxypropyl methylcellulose phthalate gels".COLLOIDS AND SURFACES A-PHYSICOCHEMICAL AND ENGINEERING ASPECTS 356.1-3(2010):89-96.
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