Fullerene-Conjugated Doxorubicin in Cells
Liu, Jia-Hui1,2,3; Cao, Li1,2; Luo, Pengju G.1,2; Yang, Sheng-Tao1,2,3; Lu, Fushen1,2; Wang, Haifang4; Meziani, Mohammed J.1,2; Haque, Sk. Anwarul1,2; Liu, Yuanfang3,4; Lacher, Sebastian1,2; Sun, Ya-Ping1,2
AbstractThe conjugation of fullerene with well-established drug molecules has been a representative strategy to impart fullerene-specific properties for improved formulation. However, conjugates involving fullerenes or other nanomaterials often differ significantly from the free drug molecules in cellular uptake and distributions. For the highly effective anticancer drug doxorubicin (DOX), its strong absorption and fluorescence in the visible spectral region enable the tracking of DOX-containing conjugates by optical techniques. In this work, a stoimetrically and structurally well-defined fullerene-DOX conjugate was studied in terms of fluorescence microscopy, including the fluorescence imaging with two-photon excitation, to examine the uptake and distribution in human breast cancer cells. The results suggested that the conjugate was distributed mostly in the cytoplasm, significantly different from free DOX molecules (predominantly in the cell nucleus, as already reported in the literature). Mechanistic implications of the results are discussed. Also discussed are potentials of conjugated DOX species as self-labeled fluorescent probes in bioimaging and other mechanistic investigations on drug delivery.
KeywordFullerenes Doxorubicin Conjugates Fluorescence Bioimaging Cells
Indexed BySCI
WOS IDWOS:000277977400018
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Cited Times:55[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorLuo, Pengju G.
Affiliation1.Clemson Univ, Dept Chem, Clemson, SC 29634 USA
2.Clemson Univ, Lab Emerging Mat & Technol, Clemson, SC 29634 USA
3.Peking Univ, Beijing Natl Lab Mol Sci, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
4.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China
Recommended Citation
GB/T 7714
Liu, Jia-Hui,Cao, Li,Luo, Pengju G.,et al. Fullerene-Conjugated Doxorubicin in Cells[J]. ACS APPLIED MATERIALS & INTERFACES,2010,2(5):1384-1389.
APA Liu, Jia-Hui.,Cao, Li.,Luo, Pengju G..,Yang, Sheng-Tao.,Lu, Fushen.,...&Sun, Ya-Ping.(2010).Fullerene-Conjugated Doxorubicin in Cells.ACS APPLIED MATERIALS & INTERFACES,2(5),1384-1389.
MLA Liu, Jia-Hui,et al."Fullerene-Conjugated Doxorubicin in Cells".ACS APPLIED MATERIALS & INTERFACES 2.5(2010):1384-1389.
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