ICCAS OpenIR
Modular Functionalization of Amphiphilic Block Copolymers via Radical-Mediated Thiol-Ene Reaction
Yue, Jun1,2; Li, Xiaoyuan1; Mo, Guojun1,2; Wang, Rui1,2; Huang, Yubin1; Jing, Xiabin1
2010-12-14
Source PublicationMACROMOLECULES
ISSN0024-9297
Volume43Issue:23Pages:9645-9654
AbstractTwo kinds of amphiphilic block copolymers, allyoxyl poly(ethylene glycol)-b-poly(L-lactide) and methoxyl poly(ethylene glycol)-b-poly(L-lactide-co-2-methyl-2-allyloxycarbonyl-propylene carbonate), were synthesized in a controllable manner. Radical mediated thiol-ene reaction was utilized to modify these two precursor block copolymers with three model mercaptans. Highly efficient and quantitative modification under UV light without adding any photoinitiators was observed by H-1 NMR spectra of the products collected at specific time points. The reaction rate was mainly dependent on molar ratio of thiol to vinyl in feeding. Quantitative transformation of the vinyl groups in both block copolymers was realized in 0.5-2 h when using excessive thiol with respect to vinyl. Using commercially available mercaptans, different functional groups were introduced into the block copolymers, thus realizing modular functionalization of target block copolymers. This method of functionalization effectively avoided traditional protection/deprotection procedures, thus greatly simplifying the process of functionalization. Precipitation and dialysis procedures were proved efficient to eliminate excess mercaptans, thus endowing the material with good biocompatibility.
DOI10.1021/ma101960d
Indexed BySCI
Language英语
WOS IDWOS:000284967000012
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:43[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/69210
Collection中国科学院化学研究所
Corresponding AuthorJing, Xiabin
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Yue, Jun,Li, Xiaoyuan,Mo, Guojun,et al. Modular Functionalization of Amphiphilic Block Copolymers via Radical-Mediated Thiol-Ene Reaction[J]. MACROMOLECULES,2010,43(23):9645-9654.
APA Yue, Jun,Li, Xiaoyuan,Mo, Guojun,Wang, Rui,Huang, Yubin,&Jing, Xiabin.(2010).Modular Functionalization of Amphiphilic Block Copolymers via Radical-Mediated Thiol-Ene Reaction.MACROMOLECULES,43(23),9645-9654.
MLA Yue, Jun,et al."Modular Functionalization of Amphiphilic Block Copolymers via Radical-Mediated Thiol-Ene Reaction".MACROMOLECULES 43.23(2010):9645-9654.
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