ICCAS OpenIR
Cysteine and pH-Responsive Hydrogel Based on a Saccharide Derivative with an Aldehyde Group
Chen, Qun1,3; Lv, Yuxia2,3; Zhang, Deqing1; Zhang, Guanxin1; Liu, Chenyang2; Zhu, Daoben1
2010-03-02
Source PublicationLANGMUIR
ISSN0743-7463
Volume26Issue:5Pages:3165-3168
AbstractFor the development of chemoresponsive hydrogel, a new saccharide-derived hydroglator 1 [methyl-4,6-O-(4'-aldehydephenylidene)-alpha-D-glucopyranoside] was synthesized and characterized. The resulting hydrogel riot only shows thermal responsiveness but also exhibits cysteine and pH responsiveness clue to the presence of aldehyde and acetal groups in 1. The release of guest molecules from the hydrogel of 1 was examined by employing compound 2 (fluorescein disodium) and compound 3[methyl-4,6-O-(2'-pyrenylidene)-alpha-D-glucopyranoside] as guest molecules. The results indicate that the release of compound 2 from the hydrogel of 1 is controlled by the diffusion process, while the release of compound 3 from the hydrogel of 1 is Facilitated by the presence of cysteine These results demonstrate (1) the proof of principle to design chemoresponsive gels by incorporating reactive groups into the gelators and (2) it is possible to stimulate the release of guest molecules from hydrogels upon addition of reactive chemicals by manipulating the intermolecular interactions among the hydrogelators and guest molecules.
DOI10.1021/la903102z
Indexed BySCI
Language英语
WOS IDWOS:000274636900029
PublisherAMER CHEMICAL SOC
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Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/69022
Collection中国科学院化学研究所
Corresponding AuthorZhang, Deqing
Affiliation1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Organ Solids Lab, Inst Chem, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Key Lab Engn Plast, Inst Chem, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Chen, Qun,Lv, Yuxia,Zhang, Deqing,et al. Cysteine and pH-Responsive Hydrogel Based on a Saccharide Derivative with an Aldehyde Group[J]. LANGMUIR,2010,26(5):3165-3168.
APA Chen, Qun,Lv, Yuxia,Zhang, Deqing,Zhang, Guanxin,Liu, Chenyang,&Zhu, Daoben.(2010).Cysteine and pH-Responsive Hydrogel Based on a Saccharide Derivative with an Aldehyde Group.LANGMUIR,26(5),3165-3168.
MLA Chen, Qun,et al."Cysteine and pH-Responsive Hydrogel Based on a Saccharide Derivative with an Aldehyde Group".LANGMUIR 26.5(2010):3165-3168.
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