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RELEASE OF IBUPROFEN FROM PEG-PLLA ELECTROSPUN FIBERS CONTAINING POLY(ETHYLENE GLYCOL)-b-POLY(alpha-HYDROXY OCTANOIC ACID) AS AN ADDITIVE
Wang, Hao1,3; Song, Hong-rui2; Chen, Xue-si3; Deng, Ying-jie1
2010-05-01
Source PublicationCHINESE JOURNAL OF POLYMER SCIENCE
ISSN0256-7679
Volume28Issue:3Pages:417-425
AbstractPoly(alpha-hydroxy octanoic acid) was first used as an additive for the preparation of electrospun ultra-fine fibers of poly(ethylene glycol)-b-poly(L-lactide) (PEG-PLLA). Ibuprofen was loaded in the electrospun ultra-fine fibers. The results from environmental scanning electron microscopy (ESEM), wide angle X-ray diffraction (WAXD) and differential scanning calorimetry (DSC) demonstrated that ibuprofen could be perfectly entrapped in the fibers electrospun from PEG-PLLA using alpha-hydroxy octanoic acid or PEG-b-poly(alpha-hydroxy octanoic acid) (PEG-PHOA) as additives. Compared with electrospun PEG-PLLA fibers which entrapped 20 wt% ibuprofen, the PEG-PLLA electrospun fibers containing PEG-PHOA exhibited integral and robust after 1 week incubated in 37 degrees C, pH 7.4 phosphate buffer solution with 10 mu g/mL proteinase K. Compared with electrospun fibers without PEG-PHOA, the concentration of proteinase K in release media had less effect on the release rate of ibuprofen. An unique release profile was found from PEG-PLLA fiber after the incorporation of PEG-PHOA. Enzyme degradation experiments demonstrated that PEG-PHOA but not alpha-hydroxy octanoic acid monomer was the crucial factor for integrity maintenance of the electrospun fibers, which may be due to the enzyme degradation tolerance property of the PEG-PHOA polymer additive.
KeywordPoly(Alpha-hydroxy Octanoic Acid) Poly(Lactic Acid) Electrospinning Fiber Ibuprofen Drug Release Proteinase k
DOI10.1007/s10118-010-9041-x
Indexed BySCI
Language英语
WOS IDWOS:000279111400015
PublisherSPRINGER
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/68996
Collection中国科学院化学研究所
Corresponding AuthorDeng, Ying-jie
Affiliation1.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Peoples R China
2.Pharmaceut Univ, Sch Pharmaceut Engn, Shenyang 110016, Peoples R China
3.Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Changchun Inst Appl Chem, Changchun 130022, Peoples R China
Recommended Citation
GB/T 7714
Wang, Hao,Song, Hong-rui,Chen, Xue-si,et al. RELEASE OF IBUPROFEN FROM PEG-PLLA ELECTROSPUN FIBERS CONTAINING POLY(ETHYLENE GLYCOL)-b-POLY(alpha-HYDROXY OCTANOIC ACID) AS AN ADDITIVE[J]. CHINESE JOURNAL OF POLYMER SCIENCE,2010,28(3):417-425.
APA Wang, Hao,Song, Hong-rui,Chen, Xue-si,&Deng, Ying-jie.(2010).RELEASE OF IBUPROFEN FROM PEG-PLLA ELECTROSPUN FIBERS CONTAINING POLY(ETHYLENE GLYCOL)-b-POLY(alpha-HYDROXY OCTANOIC ACID) AS AN ADDITIVE.CHINESE JOURNAL OF POLYMER SCIENCE,28(3),417-425.
MLA Wang, Hao,et al."RELEASE OF IBUPROFEN FROM PEG-PLLA ELECTROSPUN FIBERS CONTAINING POLY(ETHYLENE GLYCOL)-b-POLY(alpha-HYDROXY OCTANOIC ACID) AS AN ADDITIVE".CHINESE JOURNAL OF POLYMER SCIENCE 28.3(2010):417-425.
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