DNA-Molecular-Motor-Controlled Dendron Association
Sun, Yawei1; Liu, Huajie2; Xu, Lijin3; Wang, Liying1; Fan, Qing-Hua1; Liu, Dongsheng2
Source PublicationLANGMUIR
AbstractIn this letter, we described a new strategy to study the macromolecule interactions rationally controlled by the movements of a DNA molecular motor. Two amphiphilic dendrons are covalently attached to the 3' and 5' ends of a pH-driven DNA motor, a 21-mer single-stranded DNA containing four stretches of cytosine-rich sequences. The resulting DNA-dendron conjugates were purified by polyacrylamide gel electrophoresis (PAGE), and their molecular weights were confirmed by MALDI-TOF. The reversible association-dissociation of the two DNA-attached dendrons controlled by the opening and closing of the DNA motor following pH changes was verified by circular dichroism spectroscopy and DNA stability studies in aqueous solutions. The results suggest that the DNA molecular motor may serve as a new platform for studying nonspecific and specific macromolecular interactions on the molecular level.
Indexed BySCI
WOS IDWOS:000280353800006
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Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorFan, Qing-Hua
Affiliation1.Chinese Acad Sci, Beijing Natl Lab Mol Sci, CAS Key Lab Mol Recognit & Funct, Inst Chem, Beijing 100190, Peoples R China
2.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
3.Renmin Univ China, Dept Chem, Beijing 100872, Peoples R China
Recommended Citation
GB/T 7714
Sun, Yawei,Liu, Huajie,Xu, Lijin,et al. DNA-Molecular-Motor-Controlled Dendron Association[J]. LANGMUIR,2010,26(15):12496-12499.
APA Sun, Yawei,Liu, Huajie,Xu, Lijin,Wang, Liying,Fan, Qing-Hua,&Liu, Dongsheng.(2010).DNA-Molecular-Motor-Controlled Dendron Association.LANGMUIR,26(15),12496-12499.
MLA Sun, Yawei,et al."DNA-Molecular-Motor-Controlled Dendron Association".LANGMUIR 26.15(2010):12496-12499.
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