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Rh(I)-Catalyzed [(3+2)+1] Cycloaddition of 1-Yne/Ene-vinylcyclopropanes and CO: Homologous Pauson-Khand Reaction and Total Synthesis of (+/-)-alpha-Agarofuran
Jiao, Lei; Lin, Mu; Zhuo, Lian-Gang; Yu, Zhi-Xiang
2010-06-04
Source PublicationORGANIC LETTERS
ISSN1523-7060
Volume12Issue:11Pages:2528-2531
AbstractA novel Rh(I)-catalyzed [(3 + 2) + 1] cycloaddition, which can be regarded as a homologous Pauson-Khand reaction, was developed to synthesize bicyclic cyclohexenones and cyclohexanones, enabling a new approach for synthesis of six-membered carbocycles ubiquitously found in natural products and pharmaceutics. The significance of the Rh-catalyzed [(3 + 2) + 1] cycloaddition has been demonstrated by the total synthesis of a furanoid sesquiterpene natural product, a-agarofuran, in which the bicyclic skeleton was constructed by the [(3 + 2) + 1] reaction of 1-yne-VCP and CO.
DOI10.1021/ol100625e
Indexed BySCI ; IC ; CCR
Language英语
WOS IDWOS:000278062600023
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:86[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/68816
Collection中国科学院化学研究所
Corresponding AuthorYu, Zhi-Xiang
AffiliationPeking Univ, BNLMS, Coll Chem, Key Lab Bioorgan Chem & Mol Engn, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Jiao, Lei,Lin, Mu,Zhuo, Lian-Gang,et al. Rh(I)-Catalyzed [(3+2)+1] Cycloaddition of 1-Yne/Ene-vinylcyclopropanes and CO: Homologous Pauson-Khand Reaction and Total Synthesis of (+/-)-alpha-Agarofuran[J]. ORGANIC LETTERS,2010,12(11):2528-2531.
APA Jiao, Lei,Lin, Mu,Zhuo, Lian-Gang,&Yu, Zhi-Xiang.(2010).Rh(I)-Catalyzed [(3+2)+1] Cycloaddition of 1-Yne/Ene-vinylcyclopropanes and CO: Homologous Pauson-Khand Reaction and Total Synthesis of (+/-)-alpha-Agarofuran.ORGANIC LETTERS,12(11),2528-2531.
MLA Jiao, Lei,et al."Rh(I)-Catalyzed [(3+2)+1] Cycloaddition of 1-Yne/Ene-vinylcyclopropanes and CO: Homologous Pauson-Khand Reaction and Total Synthesis of (+/-)-alpha-Agarofuran".ORGANIC LETTERS 12.11(2010):2528-2531.
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