Knowledge Management System Of Institute of Chemistry，CAS
| Functional Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Mixed Anticancer Drugs | |
| Zhang, Liming1,2,3; Xia, Jingguang1; Zhao, Qinghuan1; Liu, Liwei1; Zhang, Zhijun1 | |
| 2010-02-22 | |
| Source Publication | SMALL
 |
| ISSN | 1613-6810 |
| Volume | 6Issue:4Pages:537-544 |
| Abstract | A simple synthetic route for the preparation of functional nanoscale graphene oxide (NGO), a novel nanocarrier for the loading and targeted delivery of anticancer drugs, is reported. The NGO is functionalized with sulfonic acid groups, which render it stable in physiological solution, followed by covalent binding of folic acid (FA) molecules to the NGO, thus allowing it to specifically target MCF-7 cells, human breast cancer cells with FA receptors. Furthermore, controlled loading of two anticancer drugs, doxorubicin (DOX) and camptothecin (CPT), onto the FA-conjugated NGO (FA-NGO) via pi-pi stacking and hydrophobic interactions is investigated. It is demonstrated that FA-NGO loaded with the two anticancer drugs shows specific targeting to MCF-7 cells, and remarkably high cytotoxicity compared to NGO loaded with either DOX or CPT only. Considering that the combined use of two or more drugs, a widely adopted clinical practice, often displays much better therapeutic efficacy than that of a single drug, the controlled loading and targeted delivery of mixed anticancer drugs using these graphene-based nanocarriers may find widespread application in biomedicine. |
| Keyword | Cancer Therapy Cytotoxicity Drug Delivery Graphene Oxide Nanomaterials |
| DOI | 10.1002/smll.200901680 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000275260100009 |
| Publisher | WILEY-V C H VERLAG GMBH |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.iccas.ac.cn/handle/121111/68724 |
| Collection | 中国科学院化学研究所 |
| Corresponding Author | Zhang, Zhijun |
| Affiliation | 1.Chinese Acad Sci, Suzhou Inst Nanotech & Nanobion, Suzhou 215125, Peoples R China 2.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China 3.Chinese Acad Sci, Grad Univ, Beijing 100039, Peoples R China |
| Recommended Citation GB/T 7714 | Zhang, Liming,Xia, Jingguang,Zhao, Qinghuan,et al. Functional Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Mixed Anticancer Drugs[J]. SMALL,2010,6(4):537-544. |
| APA | Zhang, Liming,Xia, Jingguang,Zhao, Qinghuan,Liu, Liwei,&Zhang, Zhijun.(2010).Functional Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Mixed Anticancer Drugs.SMALL,6(4),537-544. |
| MLA | Zhang, Liming,et al."Functional Graphene Oxide as a Nanocarrier for Controlled Loading and Targeted Delivery of Mixed Anticancer Drugs".SMALL 6.4(2010):537-544. |
| Files in This Item: | There are no files associated with this item. | |||||
Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.
Edit Comment