Pulmonary toxicity and translocation of nanodiamonds in mice
Yuan, Yuan1; Wang, Xiang2; Jia, Guang2; Liu, Jia-Hui1; Wang, Tiancheng3; Gu, Yiqun4; Yang, Sheng-Tao1; Zhen, Sen2; Wang, Haifang1,5; Liu, Yuanfang1,5
AbstractBecause of the possible health threat of nanodiamonds (NDs) to organisms, the pulmonary toxicity and translocation of NDs in different sizes in mice were investigated after intratracheal instillation administration. Biochemical assays, ultrastructural and histopathological evaluations of the lungs of the control and the ND exposed mice were carried out at 1, 7, 14 or 28 days post-exposure. Exposure to 1.0 mg/kg NDs with an average diameter of 4 nm produced a temporary lung index increase at 1 day post-exposure. NDs did not have evident adverse effects in the lungs within the studied period according to histopathological and ultrastructural investigations. Furthermore, no lipid peroxidation of the lung was observed. On the whole, intratracheally instilled NDs are of low pulmonary toxicity. In addition, the amount of NDs in alveolar decreased with time elapsed and the macrophages burdened with NDs were clearly observed in the bronchia from 1 day to 28 days post-exposure. Thus we affirm the critical role of alveolar macrophages in the main excretion pathway of NDs from the lungs, i.e. they engulf the NDs, migrate upward to the trachea by escalator/mucociliary system and finally enter the pharynx. (C) 2009 Elsevier B.V. All rights reserved.
KeywordNanodiamond Pulmonary Toxicity Intratracheal Instillation Translocation
Indexed BySCI
WOS IDWOS:000276130000005
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Cited Times:83[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorWang, Haifang
Affiliation1.Peking Univ, Coll Chem & Mol Engn, Dept Biol Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
2.Peking Univ, Sch Publ Hlth, Dept Occupat & Environm Hlth Sci, Beijing 100083, Peoples R China
3.Peking Univ, Hosp 3, Dept Clin Lab, Beijing 100083, Peoples R China
4.Matern Hosp Haidian Dist, Beijing 100080, Peoples R China
5.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China
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GB/T 7714
Yuan, Yuan,Wang, Xiang,Jia, Guang,et al. Pulmonary toxicity and translocation of nanodiamonds in mice[J]. DIAMOND AND RELATED MATERIALS,2010,19(4):291-299.
APA Yuan, Yuan.,Wang, Xiang.,Jia, Guang.,Liu, Jia-Hui.,Wang, Tiancheng.,...&Liu, Yuanfang.(2010).Pulmonary toxicity and translocation of nanodiamonds in mice.DIAMOND AND RELATED MATERIALS,19(4),291-299.
MLA Yuan, Yuan,et al."Pulmonary toxicity and translocation of nanodiamonds in mice".DIAMOND AND RELATED MATERIALS 19.4(2010):291-299.
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