ICCAS OpenIR
Complex of shikonin and beta-cyclodextrins by using supercritical carbon dioxide
He, Jun
2009-04-01
Source PublicationJOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY
ISSN0923-0750
Volume63Issue:3-4Pages:249-255
AbstractIn this work, the complex of shikonin-methyl-beta-cyclodextrin and shikonin-2-hydroxypropyl-beta-cyclodextrin were studied in supercritical carbon dioxide (sc CO(2)) at moderate pressure and temperature much lower than the melting point of shikonin. For comparing, the complex was also prepared by sealed heating method. Complex efficiency between shikonin and 2-hydroxypropyl-beta-cyclodextrin (HPBCD) was quite low. Partly formation of shikonin-methyl-beta-cyclodextrin (MBCD) was obtained by sealed heating method. Complete formation of shikonin-MBCD was obtained in sc CO(2) media in short reaction time. This complexation was accelerated and enhanced by the rise in both the reaction temperature and carbon dioxide pressure up to 100 A degrees C 100 bar. The physical state of cyclodextrins in complex reaction has remarkable influence on the complex. The aqueous solubility of shikonin could be enhanced about 75 times by complexing with MBCD.
KeywordShikonin Methyl-beta-cyclodextrin 2-hydroxypropyl-beta-cyclodextrin Complex Supercritical Carbon Dioxide
DOI10.1007/s10847-008-9514-5
Indexed BySCI
Language英语
WOS IDWOS:000264548400008
PublisherSPRINGER
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/68606
Collection中国科学院化学研究所
Corresponding AuthorHe, Jun
AffiliationChinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
He, Jun. Complex of shikonin and beta-cyclodextrins by using supercritical carbon dioxide[J]. JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY,2009,63(3-4):249-255.
APA He, Jun.(2009).Complex of shikonin and beta-cyclodextrins by using supercritical carbon dioxide.JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY,63(3-4),249-255.
MLA He, Jun."Complex of shikonin and beta-cyclodextrins by using supercritical carbon dioxide".JOURNAL OF INCLUSION PHENOMENA AND MACROCYCLIC CHEMISTRY 63.3-4(2009):249-255.
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