ICCAS OpenIR
Dual-Responsive Supramolecular Hydrogels from Water-Soluble PEG-Grafted Copolymers and Cyclodextrin
Ren, Lixia1; He, Lihong1,2; Sun, Tongchen1; Dong, Xia1; Chen, Yongming1; Huang, Jin3; Wang, Chun4
2009-09-09
Source PublicationMACROMOLECULAR BIOSCIENCE
ISSN1616-5187
Volume9Issue:9Pages:902-910
AbstractNovel temperature and pH dual-responsive hydrogels were constructed by inclusion of poly(PEGMA)-co-poly(DMA) with a-cyclodextrin in aqueous solution. The temperature- or pH-induced sol/gel transition in the hydrogels was completely reversible. Studies on structure/property relationships show that chain uniformity, graft density and copolymer concentration affect the hydrogel behavior. A dual-responsive mechanism is proposed. The in vitro release of a model drug from this hydrogel was studied. It was found that the release kinetics were greatly accelerated at higher temperature and at acidic pH conditions, indicating potential applications in controlled drug delivery.
KeywordCyclodextrins Drug Delivery Grafted Copolymers Hydrogels Stimulus Responsive
DOI10.1002/mabi.200900021
Indexed BySCI
Language英语
WOS IDWOS:000270283800011
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:53[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/68578
Collection中国科学院化学研究所
Corresponding AuthorChen, Yongming
Affiliation1.Chinese Acad Sci, Inst Chem, Div Polymer Sci & Mat, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Oak Ridge Natl Lab, Ctr Nanophase Mat Sci, Oak Ridge, TN USA
3.Wuhan Univ Technol, Coll Chem Engn, Wuhan 430070, Peoples R China
4.Univ Minnesota, Dept Biomed Engn, Minneapolis, MN 55455 USA
Recommended Citation
GB/T 7714
Ren, Lixia,He, Lihong,Sun, Tongchen,et al. Dual-Responsive Supramolecular Hydrogels from Water-Soluble PEG-Grafted Copolymers and Cyclodextrin[J]. MACROMOLECULAR BIOSCIENCE,2009,9(9):902-910.
APA Ren, Lixia.,He, Lihong.,Sun, Tongchen.,Dong, Xia.,Chen, Yongming.,...&Wang, Chun.(2009).Dual-Responsive Supramolecular Hydrogels from Water-Soluble PEG-Grafted Copolymers and Cyclodextrin.MACROMOLECULAR BIOSCIENCE,9(9),902-910.
MLA Ren, Lixia,et al."Dual-Responsive Supramolecular Hydrogels from Water-Soluble PEG-Grafted Copolymers and Cyclodextrin".MACROMOLECULAR BIOSCIENCE 9.9(2009):902-910.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Ren, Lixia]'s Articles
[He, Lihong]'s Articles
[Sun, Tongchen]'s Articles
Baidu academic
Similar articles in Baidu academic
[Ren, Lixia]'s Articles
[He, Lihong]'s Articles
[Sun, Tongchen]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Ren, Lixia]'s Articles
[He, Lihong]'s Articles
[Sun, Tongchen]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.