ICCAS OpenIR
Feasibility of biodegradable PLGA common bile duct stents: An in vitro and in vivo study
Xu, Xiaoyi3; Liu, Tongjun2; Liu, Shaohui2; Zhang, Kai2; Shen, Zhen2; Li, Yuxin3; Jing, Xiabin1
2009-05-01
Source PublicationJOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE
ISSN0957-4530
Volume20Issue:5Pages:1167-1173
AbstractThe current study investigates the feasibility of using a biodegradable polymeric stent in common bile duct (CBD) repair and reconstruction. Here, poly(l-lactide-co-glycolide) (PLGA, molar ratio LA/GA = 80/20) was processed into a circular tube- and dumbbell-shaped specimens to determine the in vitro degradation behavior in bile. The morphology, weight loss, and molecular weight changes were then investigated in conjunction with evaluations of the mechanical properties of the specimen. Circular tube-shaped PLGA stents with X-ray opacity were subsequently used in common bile duct exploration (CBDE) and primary suturing in canine models. Next, X-ray images of CBD stents in vivo were compared and levels of serum liver enzymes and a histological analysis were conducted after stent transplantation. The results showed that the PLGA stents exhibited the required biomedical properties and spontaneously disappeared from CBDs in 4-5 weeks. The degradation period and function match the requirements in repair and reconstruction of CBDs to support the duct, guide bile drainage, and reduce T-tube-related complications.
DOI10.1007/s10856-008-3672-2
Indexed BySCI
Language英语
WOS IDWOS:000264837700017
PublisherSPRINGER
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/68480
Collection中国科学院化学研究所
Corresponding AuthorJing, Xiabin
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Jilin Univ, Hosp 1, Dept Gen Surg, Changchun 130021, Peoples R China
3.NE Normal Univ, Minist Educ, Res Ctr Agr & Med Gene Engn, Natl Engn Lab Druggable Gene & Prot Screening, Changchun 130024, Peoples R China
Recommended Citation
GB/T 7714
Xu, Xiaoyi,Liu, Tongjun,Liu, Shaohui,et al. Feasibility of biodegradable PLGA common bile duct stents: An in vitro and in vivo study[J]. JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,2009,20(5):1167-1173.
APA Xu, Xiaoyi.,Liu, Tongjun.,Liu, Shaohui.,Zhang, Kai.,Shen, Zhen.,...&Jing, Xiabin.(2009).Feasibility of biodegradable PLGA common bile duct stents: An in vitro and in vivo study.JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE,20(5),1167-1173.
MLA Xu, Xiaoyi,et al."Feasibility of biodegradable PLGA common bile duct stents: An in vitro and in vivo study".JOURNAL OF MATERIALS SCIENCE-MATERIALS IN MEDICINE 20.5(2009):1167-1173.
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