ICCAS OpenIR
In vivo nanomechanical imaging of blood-vessel tissues directly in living mammals using atomic force microscopy
Mao, Youdong1,2,3; Sun, Quanmei1; Wang, Xiufeng4; Ouyang, Qi5; Han, Li6; Jiang, Lei7; Han, Dong1
2009-07-06
Source PublicationAPPLIED PHYSICS LETTERS
ISSN0003-6951
Volume95Issue:1
AbstractAtomic force microscopy (AFM) is difficult to achieve in living mammals but is necessary for understanding mechanical properties of tissues in their native form in organisms. Here we report in vivo nanomechanical imaging of blood-vessel tissues directly in living mammalians by AFM combined with surgical operations. Nanomechanical heterogeneity of blood vessels is observed across the diverse microenvironments of the same tissues in vivo. This method is further used to measure the counteractive nanomechanical changes in real time during drug-induced vasodilation and vasoconstriction in vivo, demonstrating appealing potential in characterization of in vivo nanomechanical dynamics of native tissues. (C) 2009 American Institute of Physics. [DOI:10.1063/1.3167546]
DOI10.1063/1.3167546
Indexed BySCI
Language英语
WOS IDWOS:000267983200102
PublisherAMER INST PHYSICS
Citation statistics
Cited Times:27[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/68450
Collection中国科学院化学研究所
Corresponding AuthorHan, Dong
Affiliation1.Natl Ctr Nanosci & Technol, Beijing 100080, Peoples R China
2.Harvard Univ, Sch Med, Dept Pathol, Boston, MA 02115 USA
3.Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA
4.Tsinghua Univ, Dept Phys, Beijing 100084, Peoples R China
5.Peking Univ, Sch Phys, Beijing 100871, Peoples R China
6.Chinese Acad Sci, Inst Elect Engn, Beijing 100190, Peoples R China
7.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Mao, Youdong,Sun, Quanmei,Wang, Xiufeng,et al. In vivo nanomechanical imaging of blood-vessel tissues directly in living mammals using atomic force microscopy[J]. APPLIED PHYSICS LETTERS,2009,95(1).
APA Mao, Youdong.,Sun, Quanmei.,Wang, Xiufeng.,Ouyang, Qi.,Han, Li.,...&Han, Dong.(2009).In vivo nanomechanical imaging of blood-vessel tissues directly in living mammals using atomic force microscopy.APPLIED PHYSICS LETTERS,95(1).
MLA Mao, Youdong,et al."In vivo nanomechanical imaging of blood-vessel tissues directly in living mammals using atomic force microscopy".APPLIED PHYSICS LETTERS 95.1(2009).
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