Use of MEKC for the analysis of reactant and product of Baylis-Hillman reaction
Qi, Li1,2; Cui, Kai1; Qiao, Juan1; Yang, Gengliang2; Chen, Yi1
AbstractA facile, fast and high efficiency micellar EKC has been explored for the analysis and UV detection of p-nitrobenzaldehyde and 2-[hydroxy(4-nitrophenyl)methyl]-2-cyclopenten-1-one with a buffer electrolyte of 30.0 mM tetraborate and 50.0 mM sodium taurodeoxycholate at pH 9.3. Under the optimal conditions, a linear range 10(-2) to 5.0 x 10(2) MM from 7.8 x for those analytes (r(2) > 0.99) was achieved. The LOD was 3.9 mu M for 2-[hydroxy(4-nitrophenyl)methyl]-2-cyclopenten-1-one and 7.8 mu M for p-nitrobenzaldehyde, respectively (S/N = 3). The applicability of this new method for the analysis of reactants (p-nitrobenzaldehyde and cyclopent-2-enone), catalysts (imidazole or N-methyl imidazole or 1-benzyl-imidazole) and product (2-[hydroxy(4-nitrophenyl)methyl]-2-cyclopenten-1-one) on offline Baylis-Hillman reaction was examined. The relationship between the reaction time and the amount of product has been studied. Meanwhile, three different kinds of catalysts were investigated for getting the desired moderate to good amount products. It was found that comparing with N-methyl imidazole or 1-benzyl-imidazole catalyst, imidazole-catalyzed reaction could produce more products within the same reaction time. Furthermore, the results indicated that the rate law for the investigated Baylis-Hillman reaction was second-order reaction. The rate constant for the reaction is 1.34 (+/- 0.01) x 10(-3) mol m(3)/s.
KeywordCyclopentenone Imidazole-catalyzed Baylis-hillman Reaction Mekc P-nitrobenzaldehyde
Indexed BySCI
WOS IDWOS:000266341200028
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Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorQi, Li
Affiliation1.Chinese Acad Sci, Inst Chem, Lab Analyt Chem Life, Beijing Normal Lab Mol Sci, Beijing 100190, Peoples R China
2.Hebei Univ, Coll Pharm, Baoding, Peoples R China
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GB/T 7714
Qi, Li,Cui, Kai,Qiao, Juan,et al. Use of MEKC for the analysis of reactant and product of Baylis-Hillman reaction[J]. JOURNAL OF SEPARATION SCIENCE,2009,32(9):1480-1486.
APA Qi, Li,Cui, Kai,Qiao, Juan,Yang, Gengliang,&Chen, Yi.(2009).Use of MEKC for the analysis of reactant and product of Baylis-Hillman reaction.JOURNAL OF SEPARATION SCIENCE,32(9),1480-1486.
MLA Qi, Li,et al."Use of MEKC for the analysis of reactant and product of Baylis-Hillman reaction".JOURNAL OF SEPARATION SCIENCE 32.9(2009):1480-1486.
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