ICCAS OpenIR
Synthesis of biodegradable thermo- and pH-responsive hydrogels for controlled drug release
Zhao, Changwen1,2; Zhuang, Xiuli1,3; He, Pan1,2; Xiao, Chunsheng1,2; He, Chaoliang1; Sun, Jingru1; Chen, Xuesi1; Jing, Xiabin1
2009-08-26
Source PublicationPOLYMER
ISSN0032-3861
Volume50Issue:18Pages:4308-4316
AbstractNovel intelligent hydrogels composed of biodegradable and pH-sensitive poly(L-glutamic acid) (PGA) and temperature sensitive poly(N-isopropylacrylamide-co-2-hydroxyethyl methacrylate) (PNH) were synthesized and characterized for controlled release of hydrophilic drug. The influence of pH on the equilibrium swelling ratios of the hydrogels was investigated. A higher PNH content resulted in lower equilibrium swelling ratios. Although temperature had little influence on the swelling behaviors of the hydrogels, the changes of optical transmittance of hydrogels as a function of temperature were marked, which showed that the PNH part of hydrogel exhibited hydrophobic property at temperature above the lower critical solution temperature (LCST). The biodegradation rate of the stimuli-sensitive hydrogels in the presence of enzyme was directly proportional to the PGA content. Lysozyme was chosen as a model drug and loaded into the hydrogels. The in vitro drug release experiment was carried out at different pH values and the release data suggested that both the pH and PNH content played important roles in the drug release behaviors of the hydrogels. (C) 2009 Elsevier Ltd. All rights reserved.
KeywordDouble Sensitive Hydrogel Controlled Release
DOI10.1016/j.polymer.2009.07.010
Indexed BySCI
Language英语
WOS IDWOS:000272959000004
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:111[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/68332
Collection中国科学院化学研究所
Corresponding AuthorZhuang, Xiuli
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Waseda Univ, Dept Appl Chem, Tokyo 1698555, Japan
Recommended Citation
GB/T 7714
Zhao, Changwen,Zhuang, Xiuli,He, Pan,et al. Synthesis of biodegradable thermo- and pH-responsive hydrogels for controlled drug release[J]. POLYMER,2009,50(18):4308-4316.
APA Zhao, Changwen.,Zhuang, Xiuli.,He, Pan.,Xiao, Chunsheng.,He, Chaoliang.,...&Jing, Xiabin.(2009).Synthesis of biodegradable thermo- and pH-responsive hydrogels for controlled drug release.POLYMER,50(18),4308-4316.
MLA Zhao, Changwen,et al."Synthesis of biodegradable thermo- and pH-responsive hydrogels for controlled drug release".POLYMER 50.18(2009):4308-4316.
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