Cytotoxicity of liver targeted drug-loaded alginate nanoparticles
Zhang ChuangNian1; Wang Wei1; Wang ChunHong1; Tian Qin1; Huang Wei1; Yuan Zhi1; Chen XueSi2
AbstractIn this study, novel liver targeted doxorubicin (DOX) loaded alginate (ALG) nanoparticles were prepared by CaCl(2) crosslinking method. Glycyrrhetinic acid (GA, a liver targeted molecule) modified alginate (GA-ALG) was synthesized in a heterogeneous system, and the structure of GA-ALG and the substitution degree of GA were analyzed by (1)H NMR, FT-IR and elemental analysis. The drug release profile under the simulated physiological condition and cytotoxicity experiments of drug-loaded GA-ALG nanoparticles were carried out in vitro. Transmission electron micrographs (TEM) and dynamic light scattering (DLS) analysis showed that drug-loaded GA-ALG nanoparticles have spherical shape structure with the mean hydrodynamic diameter around 214 +/- 11 nm. The drug release was shown to last 20 days, and the MTT assay suggested that drug-loaded GA-ALG nanoparticles had a distinct killing effect on 7703 hepatocellular carcinoma cells.
KeywordLiver Targeted Glycyrrhetinic Acid Alginate Cytotoxicity
Indexed BySCI
WOS IDWOS:000270191100013
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Cited Times:24[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorYuan Zhi
Affiliation1.Nankai Univ, Inst Polymer Chem, Minist Educ, Key Lab Funct Polymer Mat, Tianjin 300071, Peoples R China
2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
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GB/T 7714
Zhang ChuangNian,Wang Wei,Wang ChunHong,et al. Cytotoxicity of liver targeted drug-loaded alginate nanoparticles[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2009,52(9):1382-1387.
APA Zhang ChuangNian.,Wang Wei.,Wang ChunHong.,Tian Qin.,Huang Wei.,...&Chen XueSi.(2009).Cytotoxicity of liver targeted drug-loaded alginate nanoparticles.SCIENCE IN CHINA SERIES B-CHEMISTRY,52(9),1382-1387.
MLA Zhang ChuangNian,et al."Cytotoxicity of liver targeted drug-loaded alginate nanoparticles".SCIENCE IN CHINA SERIES B-CHEMISTRY 52.9(2009):1382-1387.
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