ICCAS OpenIR
Smart polyelectrolyte microcapsules as carriers for water-soluble small molecular drug
Song, Weixing1,2; He, Qiang1,2; Moehwald, Helmuth2; Yang, Yang3; Li, Junbai1
2009-10-15
Source PublicationJOURNAL OF CONTROLLED RELEASE
ISSN0168-3659
Volume139Issue:2Pages:160-166
AbstractHeat treatment is introduced as a simple method for the encapsulation of low molecular weight water-soluble drugs within layer-by-layer assembled microcapsules. A water-soluble drug, procainamide hydrochloride, could thus be encapsulated in large amount and enriched by more than 2 orders of magnitude in the assembled PDADMAC/PSS capsules. The shrunk capsules could control the unloading rate of drugs, and the drugs could be easily unloaded using ultrasonic treatment. The encapsulated amount could be quantitatively controlled via the drug concentration in the bulk. We also found that smaller capsules possess higher encapsulation capability. (C) 2009 Elsevier B.V. All rights reserved.
KeywordSmart Capsule Water-soluble Drug Encapsulation Layer-by-layer Assembly
DOI10.1016/j.jconrel.2009.06.010
Indexed BySCI
Language英语
WOS IDWOS:000271344200011
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:62[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/68038
Collection中国科学院化学研究所
Corresponding AuthorLi, Junbai
Affiliation1.Chinese Acad Sci, Inst Chem, BNLMS, Int Joint Lab, Beijing 100190, Peoples R China
2.Max Planck Inst Colloids & Interfaces, D-14476 Golm, Germany
3.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Song, Weixing,He, Qiang,Moehwald, Helmuth,et al. Smart polyelectrolyte microcapsules as carriers for water-soluble small molecular drug[J]. JOURNAL OF CONTROLLED RELEASE,2009,139(2):160-166.
APA Song, Weixing,He, Qiang,Moehwald, Helmuth,Yang, Yang,&Li, Junbai.(2009).Smart polyelectrolyte microcapsules as carriers for water-soluble small molecular drug.JOURNAL OF CONTROLLED RELEASE,139(2),160-166.
MLA Song, Weixing,et al."Smart polyelectrolyte microcapsules as carriers for water-soluble small molecular drug".JOURNAL OF CONTROLLED RELEASE 139.2(2009):160-166.
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