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The Surface Modification of Hydroxyapatite Nanoparticles by the Ring Opening Polymerization of gamma-Benzyl-L-glutamate N-carboxyanhydride
Wei, Junchao1,2; Liu, Aixue1,2; Chen, Lei1,2; Zhang, Peibiao1,2; Chen, Xuesi1,2; Jing, Xiabin1,2
2009-07-07
Source PublicationMACROMOLECULAR BIOSCIENCE
ISSN1616-5187
Volume9Issue:7Pages:631-638
AbstractThe surface modification of hydroxyapatite (HA) nanoparticles by the ring opening polymerization (ROP) of gamma-benzyl-L-glutamate N-carboxyanhydride (BLG-NCA) was proposed to prepare the poly(gamma-benzyl-L-glutamate) (PBLG)-grafted HA nanoparticles (PBLG-g-HA) for the first time. HA nanoparticles were firstly treated by 3-aminopropylthriethoxysilane (APS) and then the terminal amino groups of the modified HA particles initiated the ROP of BLG-NCA to obtain PBLG-g-HA. The process was monitored by XPS and FT-IR. The surface grafting amounts of PBLG on HA ranging from 12.1 to 43.1% were characterized by thermal gravimetric analysis (TGA). The powder X-ray diffraction (XRD) analysis confirmed that the ROP only underwent on the surface of HA nanoparticles without changing its bulk properties. The SEM measurement showed that the PBLG-g-HA hybrid could form an interpenetrating net structure in the self-assembly process. The PBLG-g-HA hybrid could maintain higher colloid stability than the pure HA nanoparticles. The in vitro cell cultures suggested the cell adhesion ability of PBLG-g-HA was much higher than that of pure HA.
KeywordBiomaterials Hydroxyapatite Nanoparticles Ring-opening Polymerization Surface Modification
DOI10.1002/mabi.200800324
Indexed BySCI
Language英语
WOS IDWOS:000267962700001
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:48[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/68006
Collection中国科学院化学研究所
Corresponding AuthorWei, Junchao
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Wei, Junchao,Liu, Aixue,Chen, Lei,et al. The Surface Modification of Hydroxyapatite Nanoparticles by the Ring Opening Polymerization of gamma-Benzyl-L-glutamate N-carboxyanhydride[J]. MACROMOLECULAR BIOSCIENCE,2009,9(7):631-638.
APA Wei, Junchao,Liu, Aixue,Chen, Lei,Zhang, Peibiao,Chen, Xuesi,&Jing, Xiabin.(2009).The Surface Modification of Hydroxyapatite Nanoparticles by the Ring Opening Polymerization of gamma-Benzyl-L-glutamate N-carboxyanhydride.MACROMOLECULAR BIOSCIENCE,9(7),631-638.
MLA Wei, Junchao,et al."The Surface Modification of Hydroxyapatite Nanoparticles by the Ring Opening Polymerization of gamma-Benzyl-L-glutamate N-carboxyanhydride".MACROMOLECULAR BIOSCIENCE 9.7(2009):631-638.
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