ICCAS OpenIR
Simulation Study of Protein-Mediated Vesicle Fusion
Wu, Shaogui; Guo, Hongxia
2009-01-22
Source PublicationJOURNAL OF PHYSICAL CHEMISTRY B
ISSN1520-6106
Volume113Issue:3Pages:589-591
AbstractA dissipative particle dynamics simulation method is used to probe the mechanism of protein-mediated membrane fusion. The coarse-grained models for proteins are designed based on the function of fusion proteins. Attractive forces have been introduced to produce a protein complex. The formation of protein complexes provides mechanical forces to bring membranes in proximity and trigger their merging. The whole fusion process is in good agreement with the scaffold hypothesis. Additionally, if self-defined interactions are also imposed on transmembrane segments (TMSs), their association will yield an unstable fusion pore, which can incorporate lipid and water to accomplish membrane fusion. It indicates the formation of a protein-lined pore will promote the stalk-pore transition and accelerate the fusion process.
DOI10.1021/jp808776z
Indexed BySCI
Language英语
WOS IDWOS:000262522200001
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:39[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/67944
Collection中国科学院化学研究所
Corresponding AuthorGuo, Hongxia
AffiliationChinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci,Joint Lab Polymer Sci &, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Wu, Shaogui,Guo, Hongxia. Simulation Study of Protein-Mediated Vesicle Fusion[J]. JOURNAL OF PHYSICAL CHEMISTRY B,2009,113(3):589-591.
APA Wu, Shaogui,&Guo, Hongxia.(2009).Simulation Study of Protein-Mediated Vesicle Fusion.JOURNAL OF PHYSICAL CHEMISTRY B,113(3),589-591.
MLA Wu, Shaogui,et al."Simulation Study of Protein-Mediated Vesicle Fusion".JOURNAL OF PHYSICAL CHEMISTRY B 113.3(2009):589-591.
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