ICCAS OpenIR
Hemoglobin conjugated micelles based on triblock biodegradable polymers as artificial oxygen carriers
Shi, Quan1,2; Huang, Yubin1; Chen, Xuesi1; Wu, Meng3; Sun, Jing1,2; Jing, Xiabin1
2009-10-01
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume30Issue:28Pages:5077-5085
AbstractAn artificial oxygen carrier is constructed by conjugating hemoglobin molecules to biodegradable micelles. Firstly a series of triblock copolymers (PEG-PMPC-PLA) in which the middle block contains pendant propargyl groups were synthesized and characterized. After the amphiphilic copolymer was self-assembled into core-shell micelles in aqueous solution, azidized hemoglobin molecules protected by carbon monoxide (CO) were conjugated to the micelles via click reaction between the propargyl and azido groups. The conjugation causes an increase of the micelle's mean diameter. Maximum conjugation ratio is 250 wt% in the hemoglobin-conjugated micelles (HCMs). Oxygen-binding ability of the HCMs was demonstrated by converting the CO-binding state of the HCMs into O(2)-binding state. (C) 2009 Elsevier Ltd. All rights reserved.
KeywordHemoglobin Artificial Oxygen Carrier Red Blood Cells Micelles
DOI10.1016/j.biomaterials.2009.05.082
Indexed BySCI
Language英语
WOS IDWOS:000269459900025
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:40[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/67918
Collection中国科学院化学研究所
Corresponding AuthorJing, Xiabin
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
3.Jilin Univ, Dept Mat Sci & Engn, Changchun 130025, Peoples R China
Recommended Citation
GB/T 7714
Shi, Quan,Huang, Yubin,Chen, Xuesi,et al. Hemoglobin conjugated micelles based on triblock biodegradable polymers as artificial oxygen carriers[J]. BIOMATERIALS,2009,30(28):5077-5085.
APA Shi, Quan,Huang, Yubin,Chen, Xuesi,Wu, Meng,Sun, Jing,&Jing, Xiabin.(2009).Hemoglobin conjugated micelles based on triblock biodegradable polymers as artificial oxygen carriers.BIOMATERIALS,30(28),5077-5085.
MLA Shi, Quan,et al."Hemoglobin conjugated micelles based on triblock biodegradable polymers as artificial oxygen carriers".BIOMATERIALS 30.28(2009):5077-5085.
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