ICCAS OpenIR
Synthesis and ESR Study of Covalent Connection of EMPO on L-Tyr
Du Li-Bo; Wang Guang-Qing; Han Lu; Jia Hong-Ying; Tian Qiu; Liu Yang
2009-10-10
Source PublicationCHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
ISSN0251-0790
Volume30Issue:10Pages:2009-2011
AbstractL-Tyr-EMPO, a new EMPO analogue bearing an L-tyrosine methyl ether group, was first synthesized by acylation. Various radicals, including O(2)(-center dot), (center dot)OH, (center dot)OR, and (center dot)R, have been efficiently detected and characterized via L-Tyr-EMPO. The half-life of the L-Tyr-EMPO superoxide adduct was estimated to be ca. 6.5 min. More importantly, the present study demonstrated a new synthetic strategy for covalent conjugation between cyclic-nitrone and amino group in peptides or proteins, by which the site-specifically spin trapping can be performed via antibody linked nitrone in the near future. Furthermore, with the help of the covalent link, the targeting for the areas of interest in which the monitored radical species was sitespecially generated.
KeywordSpin Trapping Bioconjugate Superoxide Anion Nitrone Free Radical
Indexed BySCI
Language英语
WOS IDWOS:000272151100019
PublisherHIGHER EDUCATION PRESS
Citation statistics
Cited Times:7[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/67912
Collection中国科学院化学研究所
Corresponding AuthorLiu Yang
AffiliationChinese Acad Sci, Inst Chem, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Du Li-Bo,Wang Guang-Qing,Han Lu,et al. Synthesis and ESR Study of Covalent Connection of EMPO on L-Tyr[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2009,30(10):2009-2011.
APA Du Li-Bo,Wang Guang-Qing,Han Lu,Jia Hong-Ying,Tian Qiu,&Liu Yang.(2009).Synthesis and ESR Study of Covalent Connection of EMPO on L-Tyr.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,30(10),2009-2011.
MLA Du Li-Bo,et al."Synthesis and ESR Study of Covalent Connection of EMPO on L-Tyr".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 30.10(2009):2009-2011.
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