ICCAS OpenIR
The splenic toxicity of water soluble multi-walled carbon nanotubes in mice
Deng, Xiaoyong1; Wu, Fei1; Liu, Zhen1; Luo, Man2; Li, Ling1; Ni, Qingshun1; Jiao, Zheng1; Wu, Minghong1; Liu, Yuanfang1,3
2009-05-01
Source PublicationCARBON
ISSN0008-6223
Volume47Issue:6Pages:1421-1428
AbstractSpleen is an important immune organ and a constituting part of the reticuloendothelial system (RES). CNTs in vivo can be readily scavenged from blood and mainly entrapped by liver, spleen and lungs. Herein, water soluble multi-walled carbon nanotubes (S-MWCNTs) were used as a model to investigate the possible toxicity of carbon nanotubes (CNTs) to mouse spleen. The toxicity of various doses of S-MWCNTs was examined by carbon clearance measurement, oxidative stress assay, histopathologic and electron-microscopic examination. Compared with the control group, phagocytic activity of RES, activity of reduced glutathione, superoxide dismutase and malondialdehyde in splenic homogenate did not change significantly in 2 months. The histopathologic examination showed no observable sign of damage in spleen; however, the accumulated S-MWCNTs gradually transferred from the red pulp to the white pulp over the exposure time and might initiate the adaptive immune response of spleen. (C) 2009 Elsevier Ltd. All rights reserved.
DOI10.1016/j.carbon.2008.12.032
Indexed BySCI
Language英语
WOS IDWOS:000265518700002
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Citation statistics
Cited Times:66[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/67740
Collection中国科学院化学研究所
Corresponding AuthorJiao, Zheng
Affiliation1.Shanghai Univ, Inst Nanochem & Nanobiol, Shanghai 200444, Peoples R China
2.Fudan Univ, ZhongShan Hosp, Dept Gerontol, Shanghai 200032, Peoples R China
3.Peking Univ, Coll Chem & Mol Engn, Dept Biol Chem, Beijing Natl Lab Mol Sci, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Deng, Xiaoyong,Wu, Fei,Liu, Zhen,et al. The splenic toxicity of water soluble multi-walled carbon nanotubes in mice[J]. CARBON,2009,47(6):1421-1428.
APA Deng, Xiaoyong.,Wu, Fei.,Liu, Zhen.,Luo, Man.,Li, Ling.,...&Liu, Yuanfang.(2009).The splenic toxicity of water soluble multi-walled carbon nanotubes in mice.CARBON,47(6),1421-1428.
MLA Deng, Xiaoyong,et al."The splenic toxicity of water soluble multi-walled carbon nanotubes in mice".CARBON 47.6(2009):1421-1428.
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