Preparation and Characterization of Temperature-responsive Porous Monoliths
Zhang Rongyue1,2; Qi Li1; Xin Peiyong1,2; Yang Gengliang3; Chen Yi1
AbstractA new temperature-responsive porous monolith has been prepared by surface-initiated activators generated by electron transfer atom transfer radical polymerization (AGET ATRP) grafting poly(N-isopropylacrylamide) (PNI-PAAm) within the pores of the porous polymer monolith. The grafting copolymerization was carried out by a method based on a continuous flow-through technique without special deoxygenation procedure needed in the general ATRP. The addition of ascorbic acid could counteract the oxidation effect of oxygen diffusing into the reaction system. The resulting grafted monolith was characterized by a mercury intrusion method and the size of macropore was 3.65 mu m, which was suitable for flow through the monolith for HPLC The thermally responsive property of the grated monolith was evaluated by HPLC using steroids with various hydrophobicities as probes. Through determination of retention factor of each steroid on the grafted monolith at different temperatures using water as mobile phase, it was found that tile slope of the plot of retention factor of each steroid versus the temperature changed around the low critical solution temperature (LCST. 32 degrees C) of PNIPAAm in water. It was relative to the grafted PNIPAAm temperature sensitivity that a hydrophobic and hydrophilic alternation Would take place around its LCST Based on this thermally responsive property, the grafted monolith was used as stationary phase for HPLC and to separate tile steroids using water as mobile phase by changing the column temperature As a mobile phase. water is much better than organic solvents concerning the environment
KeywordTemperature-responsive Monolith Poly(N-isopropylacrylamide) Atom Transfer Radical Polymerization Hplc Steroid
Indexed BySCI
WOS IDWOS:000272761600021
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Cited Times:5[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorQi Li
Affiliation1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Lab Analyt Chem Life Sci, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Hebei Univ, Coll Pharm, Baoding 071002, Hebei, Peoples R China
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GB/T 7714
Zhang Rongyue,Qi Li,Xin Peiyong,et al. Preparation and Characterization of Temperature-responsive Porous Monoliths[J]. CHINESE JOURNAL OF CHEMISTRY,2009,27(11):2229-2236.
APA Zhang Rongyue,Qi Li,Xin Peiyong,Yang Gengliang,&Chen Yi.(2009).Preparation and Characterization of Temperature-responsive Porous Monoliths.CHINESE JOURNAL OF CHEMISTRY,27(11),2229-2236.
MLA Zhang Rongyue,et al."Preparation and Characterization of Temperature-responsive Porous Monoliths".CHINESE JOURNAL OF CHEMISTRY 27.11(2009):2229-2236.
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