ICCAS OpenIR
On-line electrochemical measurements of cerebral hypoxanthine of freely moving rats
Zhang ZiPin; Lin YuQing; Mao LanQun
2009-10-01
Source PublicationSCIENCE IN CHINA SERIES B-CHEMISTRY
ISSN1006-9291
Volume52Issue:10Pages:1677-1682
AbstractThis study demonstrates an on-line method for continuous measurements of cerebral hypoxanthine in the freely moving rats with integration of selective electrochemical biosensing with in vivo microdialysis sampling. The selective electrochemical biosensing is achieved by using xanthine oxidase (XOD) as the specific sensing element and Prussian blue (PB) as the electrocatalyst for the reduction of H(2)O(2) generated from the oxidase-catalyzed reaction. The method is virtually interference-free from the coexisting electroactive species in the brain and exhibits a good stability and reproducibility. Upon integrated with in vivo microdialysis, the on-line method is well suitable for continuous measurements of cerebral hypoxanthine of freely moving rats, which is illustrated by the measurements of the microdialysates after the hypoxanthine standard was externally infused into the rat brain. This study essentially offers a facile on-line electrochemical approach to continuous measurements of cerebral hypoxanthine and could find some interesting applications in physiological and pathological investigations associated with hypoxanthine.
KeywordOn-line Method Electrochemical Biosensor Hypoxanthine Rat Brain
DOI10.1007/s11426-009-0231-8
Indexed BySCI
Language英语
WOS IDWOS:000271168500019
PublisherSCIENCE PRESS
Citation statistics
Cited Times:2[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/67636
Collection中国科学院化学研究所
Corresponding AuthorMao LanQun
AffiliationChinese Acad Sci, Beijing Natl Lab Mol Sci, Inst Chem, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhang ZiPin,Lin YuQing,Mao LanQun. On-line electrochemical measurements of cerebral hypoxanthine of freely moving rats[J]. SCIENCE IN CHINA SERIES B-CHEMISTRY,2009,52(10):1677-1682.
APA Zhang ZiPin,Lin YuQing,&Mao LanQun.(2009).On-line electrochemical measurements of cerebral hypoxanthine of freely moving rats.SCIENCE IN CHINA SERIES B-CHEMISTRY,52(10),1677-1682.
MLA Zhang ZiPin,et al."On-line electrochemical measurements of cerebral hypoxanthine of freely moving rats".SCIENCE IN CHINA SERIES B-CHEMISTRY 52.10(2009):1677-1682.
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