ICCAS OpenIR
Optical investigation of diffusion of levofloxacin mesylate in agarose hydrogel
Tan, Shuaixia1,2; Dai, Hongjun1,2; Wu, Juejie1,3; Zhao, Ning1; Zhang, Xiaoli1; Xu, Jian1
2009-09-01
Source PublicationJOURNAL OF BIOMEDICAL OPTICS
ISSN1083-3668
Volume14Issue:5
AbstractReal-time electronic speckle pattern interferometry method has been applied to study the diffusion behavior of levofloxacin mesylate (MSALVFX) in agarose hydrogel. The results show that the diffusivity of solute decreases with the increase of concentration of agarose and adapts to Kohlrausch's law. Furthermore, Amsden's model, based on the retardance effect associated with polymer chain flexibility, was employed to simulate the diffusion behavior. The consistent results suggest that the retardance effect dominates the diffusion process of MSALFVX in hydrogel; moreover, polymer chain flexibility greatly affects drug transport within the polymer matrix. (C) 2009 Society of Photo-Optical Instrumentation Engineers. [DOI: 10.1117/1.3227034]
KeywordAgarose Hydrogel Diffusion Electronic Speckle Pattern Interferometry Levofloxacin Mesylate
DOI10.1117/1.3227034
Indexed BySCI
Language英语
WOS IDWOS:000271746100004
PublisherSPIE-SOC PHOTOPTICAL INSTRUMENTATION ENGINEERS
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/67586
Collection中国科学院化学研究所
Corresponding AuthorZhao, Ning
Affiliation1.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Univ, Beijing 100190, Peoples R China
3.Xiangtan Univ, Coll Chem, Xiangtan 411105, Hunan, Peoples R China
Recommended Citation
GB/T 7714
Tan, Shuaixia,Dai, Hongjun,Wu, Juejie,et al. Optical investigation of diffusion of levofloxacin mesylate in agarose hydrogel[J]. JOURNAL OF BIOMEDICAL OPTICS,2009,14(5).
APA Tan, Shuaixia,Dai, Hongjun,Wu, Juejie,Zhao, Ning,Zhang, Xiaoli,&Xu, Jian.(2009).Optical investigation of diffusion of levofloxacin mesylate in agarose hydrogel.JOURNAL OF BIOMEDICAL OPTICS,14(5).
MLA Tan, Shuaixia,et al."Optical investigation of diffusion of levofloxacin mesylate in agarose hydrogel".JOURNAL OF BIOMEDICAL OPTICS 14.5(2009).
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