ICCAS OpenIR
Cell outer membrane mimetic modification of a cross-linked chitosan surface to improve its hemocompatibility
Huangfu, Peng-bo1; Gong, Ming1; Zhang, Cunfu2; Yang, Shan1; Zhao, Jiang2; Gong, Yong-kuan1
2009-07-01
Source PublicationCOLLOIDS AND SURFACES B-BIOINTERFACES
ISSN0927-7765
Volume71Issue:2Pages:268-274
AbstractA novel strategy has been developed to improve the hemocompatibility of chitosan surface by cell outer membrane mimetic structure able to reduce protein adsorption and cell adhesion. Phosphorylcholine dichloride was synthesized and grafted onto a glutaraldehyde-cross-linked chitosan (CS-GA) film surface to prepare phosphorylcholine-coated CS-GA film (CS-GA-PC) through a heterogeneous reaction process. The spectroscopic and contact angle characterization show that a cell outer membrane mimetic structure was formed on the cross-linked chitosan surface, and the significantly improved hemocompatibility of the modified surface was shown by a suppression of 94% on platelet adhesion, a suppression of 60-70% for bovine plasma fibrinogen and bovine serum albumin adsorptions. These results demonstrated that this cell outer membrane mimetic surface modification with phosphorylcholine dichloride is a promising strategy to improve the hemocompatibility of chitosan. (C) 2009 Elsevier BY. All rights reserved.
KeywordPhosphorylcholine Chitosan Hemocompatibility Surface Modification Contact Angle Xps
DOI10.1016/j.colsurfb.2009.02.014
Indexed BySCI
Language英语
WOS IDWOS:000266897900016
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:26[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/67580
Collection中国科学院化学研究所
Corresponding AuthorGong, Yong-kuan
Affiliation1.NW Univ Xian, Key Lab Synthet & Nat Funct Mol Chem, Minist Educ, Coll Chem & Mat Sci, Xian 710069, Peoples R China
2.Chinese Acad Sci, Inst Chem, State Key Lab Polymer Phys & Chem, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Huangfu, Peng-bo,Gong, Ming,Zhang, Cunfu,et al. Cell outer membrane mimetic modification of a cross-linked chitosan surface to improve its hemocompatibility[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2009,71(2):268-274.
APA Huangfu, Peng-bo,Gong, Ming,Zhang, Cunfu,Yang, Shan,Zhao, Jiang,&Gong, Yong-kuan.(2009).Cell outer membrane mimetic modification of a cross-linked chitosan surface to improve its hemocompatibility.COLLOIDS AND SURFACES B-BIOINTERFACES,71(2),268-274.
MLA Huangfu, Peng-bo,et al."Cell outer membrane mimetic modification of a cross-linked chitosan surface to improve its hemocompatibility".COLLOIDS AND SURFACES B-BIOINTERFACES 71.2(2009):268-274.
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