ICCAS OpenIR
Stabilizing parallel G-quadruplex DNA by a new class of ligands: Two non-planar alkaloids through interaction in lateral grooves
Li, Qian1,3; Xiang, Junfeng1; Li, Xudong2; Chen, Lirong2; Xu, Xiaojie2; Tang, Yalin1; Zhou, Qiuju1,3; Li, Lin1,3; Zhang, Hong1; Sun, Hongxia1; Guan, Aijiao1,3; Yang, Qianfan1,3; Yang, Shu1,3; Xu, Guangzhi1
2009-07-01
Source PublicationBIOCHIMIE
ISSN0300-9084
Volume91Issue:7Pages:811-819
AbstractHuman DNA sequences consisting of tandem guanine (G) nucleotides can fold into a four-stranded structure named G-quadruplex via Hoogsteen hydrogen bonding. As the sequences forming G-quadruplex exist in essential regions of eukaryotic chromosomes and are involved in many important biological processes, the study of their biological functions has currently become a hotspot. Compounds selectively binding and stabilizing G-quadruplex structures have the potential to inhibit telomerase activity or alter oncogene expression levels and thus may act as antitumor agents. Most of reported G-quadruplex ligands generally have planar structures which stabilize G-quadruplex by pi-pi stacking. However, based on a pharmacophore-based virtual screening two non-planar G-quadruplex ligands were found. These two ligands exhibit good capability for G-quadruplex stabilization and prefer binding to paralleled G-quadruplex rather than to duplex DNA. The binding of these ligands to G-quadruplex may result from groove binding at a 2:1 stoichiometry. These results have shown that planar structures are not essential for G-quadruplex stabilizers, which may represent a new class of G-quadruplex-targeted agents as potential antitumor drugs. (C) 2009 Elsevier Masson SAS. All rights reserved.
KeywordG-quadruplex Groove Binding Non-planar Alkaloids
DOI10.1016/j.biochi.2009.03.007
Indexed BySCI
Language英语
WOS IDWOS:000267628700001
PublisherELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER
Citation statistics
Cited Times:56[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/67544
Collection中国科学院化学研究所
Corresponding AuthorTang, Yalin
Affiliation1.Chinese Acad Sci, Inst Chem, Ctr Mol Sci,BNLMS, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100190, Peoples R China
2.Peking Univ, BNLMS, State Key Lab Rare Earth Mat Chem & Applicat, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Li, Qian,Xiang, Junfeng,Li, Xudong,et al. Stabilizing parallel G-quadruplex DNA by a new class of ligands: Two non-planar alkaloids through interaction in lateral grooves[J]. BIOCHIMIE,2009,91(7):811-819.
APA Li, Qian.,Xiang, Junfeng.,Li, Xudong.,Chen, Lirong.,Xu, Xiaojie.,...&Xu, Guangzhi.(2009).Stabilizing parallel G-quadruplex DNA by a new class of ligands: Two non-planar alkaloids through interaction in lateral grooves.BIOCHIMIE,91(7),811-819.
MLA Li, Qian,et al."Stabilizing parallel G-quadruplex DNA by a new class of ligands: Two non-planar alkaloids through interaction in lateral grooves".BIOCHIMIE 91.7(2009):811-819.
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