ICCAS OpenIR
Specific DNA G-Quadruplexes Bind to Ethanolamines
Cheng, Xiaohong1,2; Liu, Xiangjun1; Bing, Tao1,2; Zhao, Rui1; Xiong, Shaoxiang1; Shangguan, Dihua1
2009-10-01
Source PublicationBIOPOLYMERS
ISSN0006-3525
Volume91Issue:10Pages:874-883
AbstractA significant number of G-quadruplex-forming sequences have been revealed in human genome by bioinfomatic searches, implying that G-quadruplexes may be involved in important biological processes and may be new chemotherapeutic targets. Therefore, it is important to discover the potential interactions of G-quadruplexes with other molecules or groups. Here we describe a class of G-quadruplexes, which can bind to ethanolamine groups that widely exist in biomolecules and drug molecules. The specific interaction of these G-quadruplexes with ethanolamine groups was identified by high performance affinity chromatography (HPAC) using immobilized ethanolamine and diethanolamine as stationary phase reagents. The circular dichroism (CD) spectra and native polyacrylamide gel electrophoresis (PAGE) show that these ethanolamine binding quadruplexes adopt an intramolecularly parallel structure. The relationship of ethanolamine binding and G-quadruplexe structure provides new clues for the G-quadruplex-related studies as well as for the molecular designs of therapeutic reagents. (C) 2009 Wiley Periodicals, Inc. Biopolyiners 91: 874-883,2009.
KeywordG-quadruplexes Molecular Interaction Ethanolamine
DOI10.1002/bip.21272
Indexed BySCI
Language英语
WOS IDWOS:000269267500007
PublisherJOHN WILEY & SONS INC
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/67496
Collection中国科学院化学研究所
Corresponding AuthorShangguan, Dihua
Affiliation1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Cheng, Xiaohong,Liu, Xiangjun,Bing, Tao,et al. Specific DNA G-Quadruplexes Bind to Ethanolamines[J]. BIOPOLYMERS,2009,91(10):874-883.
APA Cheng, Xiaohong,Liu, Xiangjun,Bing, Tao,Zhao, Rui,Xiong, Shaoxiang,&Shangguan, Dihua.(2009).Specific DNA G-Quadruplexes Bind to Ethanolamines.BIOPOLYMERS,91(10),874-883.
MLA Cheng, Xiaohong,et al."Specific DNA G-Quadruplexes Bind to Ethanolamines".BIOPOLYMERS 91.10(2009):874-883.
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