Specific DNA G-Quadruplexes Bind to Ethanolamines
Cheng, Xiaohong1,2; Liu, Xiangjun1; Bing, Tao1,2; Zhao, Rui1; Xiong, Shaoxiang1; Shangguan, Dihua1
Source PublicationBIOPOLYMERS
AbstractA significant number of G-quadruplex-forming sequences have been revealed in human genome by bioinfomatic searches, implying that G-quadruplexes may be involved in important biological processes and may be new chemotherapeutic targets. Therefore, it is important to discover the potential interactions of G-quadruplexes with other molecules or groups. Here we describe a class of G-quadruplexes, which can bind to ethanolamine groups that widely exist in biomolecules and drug molecules. The specific interaction of these G-quadruplexes with ethanolamine groups was identified by high performance affinity chromatography (HPAC) using immobilized ethanolamine and diethanolamine as stationary phase reagents. The circular dichroism (CD) spectra and native polyacrylamide gel electrophoresis (PAGE) show that these ethanolamine binding quadruplexes adopt an intramolecularly parallel structure. The relationship of ethanolamine binding and G-quadruplexe structure provides new clues for the G-quadruplex-related studies as well as for the molecular designs of therapeutic reagents. (C) 2009 Wiley Periodicals, Inc. Biopolyiners 91: 874-883,2009.
KeywordG-quadruplexes Molecular Interaction Ethanolamine
Indexed BySCI
WOS IDWOS:000269267500007
Citation statistics
Cited Times:23[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorShangguan, Dihua
Affiliation1.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Cheng, Xiaohong,Liu, Xiangjun,Bing, Tao,et al. Specific DNA G-Quadruplexes Bind to Ethanolamines[J]. BIOPOLYMERS,2009,91(10):874-883.
APA Cheng, Xiaohong,Liu, Xiangjun,Bing, Tao,Zhao, Rui,Xiong, Shaoxiang,&Shangguan, Dihua.(2009).Specific DNA G-Quadruplexes Bind to Ethanolamines.BIOPOLYMERS,91(10),874-883.
MLA Cheng, Xiaohong,et al."Specific DNA G-Quadruplexes Bind to Ethanolamines".BIOPOLYMERS 91.10(2009):874-883.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Cheng, Xiaohong]'s Articles
[Liu, Xiangjun]'s Articles
[Bing, Tao]'s Articles
Baidu academic
Similar articles in Baidu academic
[Cheng, Xiaohong]'s Articles
[Liu, Xiangjun]'s Articles
[Bing, Tao]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Cheng, Xiaohong]'s Articles
[Liu, Xiangjun]'s Articles
[Bing, Tao]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.