ICCAS OpenIR
Preparation and characterization of monolithic column by grafting pH-responsive polymer
Wei, Xiaoyi1,2; Qi, Li1; Yang, Gengliang3; Wang, Fuyi1
2009-08-15
Source PublicationTALANTA
ISSN0039-9140
Volume79Issue:3Pages:739-745
AbstractA novel modified monolithic column with pH-responsive polymer chains was prepared by grafting methacrylic acid onto the poly(glycidyl methacrylate-co-ethylene dimethacrylate) monolith. The grafting polymerization was achieved in an in situ manner which was performed by pumping methacrylic acid directly through an acidic hydrolysis monolithic column using potassium peroxydisulfate initiated free-radical polymerization. The grafted monolithic column was demonstrated to be the pH-responsive to the pore structure and the chromatographic characterization. The permeability of the column and the retention factors of five benzene homologues decreased due to the conformational changes of the polymer chains when the pH of mobile phase increased from 4.5 to 7.5. Furthermore, the modified monolithic column was used as the pH-responsive stationary phase and exhibited an excellent separation of four basic proteins. (C) 2009 Elsevier B.V. All rights reserved.
KeywordMonolithic Column Graft Methacrylic Acid Ph-responsive Polymer
DOI10.1016/j.talanta.2009.04.062
Indexed BySCI
Language英语
WOS IDWOS:000268346800028
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:29[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/67384
Collection中国科学院化学研究所
Corresponding AuthorQi, Li
Affiliation1.Chinese Acad Sci, Inst Chem, Lab Analyt Chem Life Sci, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
3.Hebei Univ, Coll Pharm, Baoding 071002, Peoples R China
Recommended Citation
GB/T 7714
Wei, Xiaoyi,Qi, Li,Yang, Gengliang,et al. Preparation and characterization of monolithic column by grafting pH-responsive polymer[J]. TALANTA,2009,79(3):739-745.
APA Wei, Xiaoyi,Qi, Li,Yang, Gengliang,&Wang, Fuyi.(2009).Preparation and characterization of monolithic column by grafting pH-responsive polymer.TALANTA,79(3),739-745.
MLA Wei, Xiaoyi,et al."Preparation and characterization of monolithic column by grafting pH-responsive polymer".TALANTA 79.3(2009):739-745.
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