ICCAS OpenIR
Multi-morphological biodegradable PLGE nanoparticles and their drug release behavior
Zhang, Hanwei; Bei, Jianzhong; Wang, Shenguo
2009
Source PublicationBIOMATERIALS
ISSN0142-9612
Volume30Issue:1Pages:100-107
AbstractA series of amphiphilic tri-block copolymers based on poly(lactide-co-glycolide)-b-poly(ethylene oxide)b-poly(lactide-co-glycolide) (PLGE) with various segment ratios of PEO/PLGA and segment lengths of PEO were synthesized. Multi -morphological biodegradable nanoparticles - PLGE-NPs were fabricated by an improved emulsion/solvent evaporation technique in the absence of surfactant. By adjusting segment ratio of PLGA/PEO (w/w) and molecular weight of PEO, various morphological and nanoscale sized spheres, elliptic spheres, short rods and threads could be formed. The auto-assembling mechanism of the PLGE-NPs and influencing effectors of composition of the PLGE on morphology of the PLGE-NPs were discussed. The PLGE-NPs were biodegradable, and the factors that affected the degradation rate of the PLGE-NPs were also discussed. By using the amphiphilic PLGE polymer, the biodegradable nanoscale immunosuppressive agent - multi-morphological Cyclosporine (CsA)-loaded PLGE-NPs was fabricated. CsA release behavior of the CsA-loaded PLGE-NPs in vitro was determined, and the effect factors on CsA release behavior of the CsA-loaded PLGE-NPs were discussed. (C) 2008 Elsevier Ltd. All rights reserved.
KeywordPoly(Lactide-co-glycolide)-b-peo-b-Poly(Lactide-co-glycolide) Tri-block coPolymer (Plge) Nanoparticles (Nps) Multi-morphology Csa Drug Delivery
DOI10.1016/j.biomaterials.2008.09.016
Indexed BySCI
Language英语
WOS IDWOS:000261139100013
PublisherELSEVIER SCI LTD
Citation statistics
Cited Times:15[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/67318
Collection中国科学院化学研究所
Corresponding AuthorWang, Shenguo
AffiliationChinese Acad Sci, Inst Chem, BNLMS, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Hanwei,Bei, Jianzhong,Wang, Shenguo. Multi-morphological biodegradable PLGE nanoparticles and their drug release behavior[J]. BIOMATERIALS,2009,30(1):100-107.
APA Zhang, Hanwei,Bei, Jianzhong,&Wang, Shenguo.(2009).Multi-morphological biodegradable PLGE nanoparticles and their drug release behavior.BIOMATERIALS,30(1),100-107.
MLA Zhang, Hanwei,et al."Multi-morphological biodegradable PLGE nanoparticles and their drug release behavior".BIOMATERIALS 30.1(2009):100-107.
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