ICCAS OpenIR
Spectroscopic studies of the effect of the metal ions on the structure of mucin
Su, Yunlan1,2; Xu, Yizhuang1; Yang, Limin3,4; Weng, Shifu1; Soloway, R. D.5; Wang, Dujin2; Wu, Jinguang1
2009-02-28
Source PublicationJOURNAL OF MOLECULAR STRUCTURE
ISSN0022-2860
Volume920Issue:1-3Pages:8-13
AbstractIn this study the binding characteristics of mucin to calcium ion was examined by Fourier Transform Infrared (FT-IR), FT-Raman, Transmission Electron Microscope (TEM), and Dynamic Light Scattering(DLS) methods. The binding site of the interaction between mucin and calcium ions could be confirmed by FT-IR and FT-Raman techniques. When the concentration of Ca(2+) is relatively low, Ca(2+) prefers to coordinate with the carbohydrate moiety of mucins. When the concentration of Ca(2+) is high, Ca(2+) will also interact with the protein moiety of mucins. The morphology and the size Of CaCl(2)-mucin solution could be obtained by TEM and DLS methods, respectively. The hydrodynamic radius of CaCl(2)-mucin mixture decreases compared with pure mucin solution, which may result from that Ca(2+) induces a contraction or folding of mucin chains to forma more compact configuration. The activity of the cations in modifying the structure of mucin may be of great importance for the biological function in normal and disease states. (C) 2008 Elsevier B.V. All rights reserved.
KeywordMucin Metal Ion Binding Spectroscopic Study
DOI10.1016/j.molstruc.2008.10.014
Indexed BySCI
Language英语
WOS IDWOS:000264251400002
PublisherELSEVIER SCIENCE BV
Citation statistics
Cited Times:11[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/67186
Collection中国科学院化学研究所
Corresponding AuthorSu, Yunlan
Affiliation1.Peking Univ, State Key Lab Rare Earth Mat Chem & Applicat, Coll Chem & Mol Engn, Beijing 100871, Peoples R China
2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Engn Plast, Joint Lab Polymer Sci & Mat,Inst Chem, Beijing 100080, Peoples R China
3.Peking Univ, Key Lab Heavy Ion Phys, Minist Educ, Beijing 100871, Peoples R China
4.Peking Univ, Sch Phys, Inst Heavy Ion Phys, Beijing 100871, Peoples R China
5.Univ Texas Galveston, Div Gastroenterol, Med Branch, Galveston, TX 77555 USA
Recommended Citation
GB/T 7714
Su, Yunlan,Xu, Yizhuang,Yang, Limin,et al. Spectroscopic studies of the effect of the metal ions on the structure of mucin[J]. JOURNAL OF MOLECULAR STRUCTURE,2009,920(1-3):8-13.
APA Su, Yunlan.,Xu, Yizhuang.,Yang, Limin.,Weng, Shifu.,Soloway, R. D..,...&Wu, Jinguang.(2009).Spectroscopic studies of the effect of the metal ions on the structure of mucin.JOURNAL OF MOLECULAR STRUCTURE,920(1-3),8-13.
MLA Su, Yunlan,et al."Spectroscopic studies of the effect of the metal ions on the structure of mucin".JOURNAL OF MOLECULAR STRUCTURE 920.1-3(2009):8-13.
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