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| Spectroscopic studies of the effect of the metal ions on the structure of mucin | |
| Su, Yunlan1,2; Xu, Yizhuang1; Yang, Limin3,4; Weng, Shifu1; Soloway, R. D.5; Wang, Dujin2; Wu, Jinguang1 | |
| 2009-02-28 | |
| Source Publication | JOURNAL OF MOLECULAR STRUCTURE
 |
| ISSN | 0022-2860 |
| Volume | 920Issue:1-3Pages:8-13 |
| Abstract | In this study the binding characteristics of mucin to calcium ion was examined by Fourier Transform Infrared (FT-IR), FT-Raman, Transmission Electron Microscope (TEM), and Dynamic Light Scattering(DLS) methods. The binding site of the interaction between mucin and calcium ions could be confirmed by FT-IR and FT-Raman techniques. When the concentration of Ca(2+) is relatively low, Ca(2+) prefers to coordinate with the carbohydrate moiety of mucins. When the concentration of Ca(2+) is high, Ca(2+) will also interact with the protein moiety of mucins. The morphology and the size Of CaCl(2)-mucin solution could be obtained by TEM and DLS methods, respectively. The hydrodynamic radius of CaCl(2)-mucin mixture decreases compared with pure mucin solution, which may result from that Ca(2+) induces a contraction or folding of mucin chains to forma more compact configuration. The activity of the cations in modifying the structure of mucin may be of great importance for the biological function in normal and disease states. (C) 2008 Elsevier B.V. All rights reserved. |
| Keyword | Mucin Metal Ion Binding Spectroscopic Study |
| DOI | 10.1016/j.molstruc.2008.10.014 |
| Indexed By | SCI |
| Language | 英语 |
| WOS ID | WOS:000264251400002 |
| Publisher | ELSEVIER SCIENCE BV |
| Citation statistics | |
| Document Type | 期刊论文 |
| Identifier | http://ir.iccas.ac.cn/handle/121111/67186 |
| Collection | 中国科学院化学研究所 |
| Corresponding Author | Su, Yunlan |
| Affiliation | 1.Peking Univ, State Key Lab Rare Earth Mat Chem & Applicat, Coll Chem & Mol Engn, Beijing 100871, Peoples R China 2.Chinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Engn Plast, Joint Lab Polymer Sci & Mat,Inst Chem, Beijing 100080, Peoples R China 3.Peking Univ, Key Lab Heavy Ion Phys, Minist Educ, Beijing 100871, Peoples R China 4.Peking Univ, Sch Phys, Inst Heavy Ion Phys, Beijing 100871, Peoples R China 5.Univ Texas Galveston, Div Gastroenterol, Med Branch, Galveston, TX 77555 USA |
| Recommended Citation GB/T 7714 | Su, Yunlan,Xu, Yizhuang,Yang, Limin,et al. Spectroscopic studies of the effect of the metal ions on the structure of mucin[J]. JOURNAL OF MOLECULAR STRUCTURE,2009,920(1-3):8-13. |
| APA | Su, Yunlan.,Xu, Yizhuang.,Yang, Limin.,Weng, Shifu.,Soloway, R. D..,...&Wu, Jinguang.(2009).Spectroscopic studies of the effect of the metal ions on the structure of mucin.JOURNAL OF MOLECULAR STRUCTURE,920(1-3),8-13. |
| MLA | Su, Yunlan,et al."Spectroscopic studies of the effect of the metal ions on the structure of mucin".JOURNAL OF MOLECULAR STRUCTURE 920.1-3(2009):8-13. |
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