ICCAS OpenIR
Online Purification and Screening of Nisoldipine with a Novel Poly(vinyl ester) Resin Monolithic Column
Feng, Xiaojuan1; Liu, Haiyan1; Yang, Gengliang1,2; Ren, Bingnan1; Yang, Xinru1; Yang, Guanqun1
2009-03-01
Source PublicationCHROMATOGRAPHIA
ISSN0009-5893
Volume69Issue:5-6Pages:403-407
AbstractA monolithic column, prepared from a vinyl ester resin used as both monomer and cross-linking agent, has been used to remove matrix compounds from biological fluid. Using this column, nisoldipine in human plasma samples could be enriched online and the protein could be eluted. For this method of extraction, response (peak area) was a linear function of concentration in the range 2-80 ng mL(-1), with a linear regression coefficient of 0.99985. The limit of detection for nisoldipine in plasma was 1.2 ng mL(-1). For nisoldipine at concentrations of 10, 30, and 70 ng mL(-1) RSD were 4.33, 6.63, and 4.57%, respectively. Recovery for both extraction (> 73.6%) and the entire analytical method (> 90.7%) were acceptable for screening of plasma for nisoldipine. The 12-hour pharmacokinetic profile of nisoldipine in mice after oral administration (0.3 mg kg(-1)) was investigated. The results indicated the method could be used for therapeutic monitoring of nisoldipine and enabled simple and rapid assay of the drug in plasma.
KeywordMonolithic Column Vinyl Ester Resin Deproteinization Enrichment Nisoldipine
DOI10.1365/s10337-008-0904-z
Indexed BySCI
Language英语
WOS IDWOS:000263826600001
PublisherVIEWEG
Citation statistics
Cited Times:3[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/67130
Collection中国科学院化学研究所
Corresponding AuthorYang, Gengliang
Affiliation1.Hebei Univ, Coll Pharm, Baoding 071002, Peoples R China
2.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Feng, Xiaojuan,Liu, Haiyan,Yang, Gengliang,et al. Online Purification and Screening of Nisoldipine with a Novel Poly(vinyl ester) Resin Monolithic Column[J]. CHROMATOGRAPHIA,2009,69(5-6):403-407.
APA Feng, Xiaojuan,Liu, Haiyan,Yang, Gengliang,Ren, Bingnan,Yang, Xinru,&Yang, Guanqun.(2009).Online Purification and Screening of Nisoldipine with a Novel Poly(vinyl ester) Resin Monolithic Column.CHROMATOGRAPHIA,69(5-6),403-407.
MLA Feng, Xiaojuan,et al."Online Purification and Screening of Nisoldipine with a Novel Poly(vinyl ester) Resin Monolithic Column".CHROMATOGRAPHIA 69.5-6(2009):403-407.
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