ICCAS OpenIR
Single-molecule imaging reveals transforming growth factor-beta-induced type II receptor dimerization
Zhang, Wei1; Jiang, Yaxin1; Wang, Qiang2; Ma, Xinyong1; Xiao, Zeyu1; Zuo, Wei2; Fang, Xiaohong1; Chen, Guang2
2009-09-15
Source PublicationPROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA
ISSN0027-8424
Volume106Issue:37Pages:15679-15683
AbstractTransforming growth factor-beta (TGF-beta) elicits its signals through two transmembrane serine/threonine kinase receptors, type II (T beta RII) and type I receptors. It is generally believed that the initial receptor dimerization is an essential event for receptor activation. However, previous studies suggested that TGF-beta signals by binding to the preexisting T beta RII homodimer. Here, using single molecule microscopy to image green fluorescent protein (GFP)-labeled T beta RII on the living cell surface, we demonstrated that the receptor could exist as monomers at the low expression level in resting cells and dimerize upon TGF-beta stimulation. This work reveals a model in which the activation of serine-threonine kinase receptors is also accomplished via dimerization of monomers, suggesting that receptor dimerization is a general mechanism for ligand-induced receptor activation.
KeywordSerine/threonine Kinase Receptor Subunit Stoichiometry
DOI10.1073/pnas.0908279106
Indexed BySCI
Language英语
WOS IDWOS:000269806600033
PublisherNATL ACAD SCIENCES
Citation statistics
Cited Times:75[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/66862
Collection中国科学院化学研究所
Corresponding AuthorFang, Xiaohong
Affiliation1.Chinese Acad Sci, Key Lab Mol Nanostruct & Nanotechnol, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
2.Tsinghua Univ, Dept Biol Sci & Biotechnol, State Key Lab Biomembrane & Membrane Biotechnol, Beijing 100084, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Wei,Jiang, Yaxin,Wang, Qiang,et al. Single-molecule imaging reveals transforming growth factor-beta-induced type II receptor dimerization[J]. PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,2009,106(37):15679-15683.
APA Zhang, Wei.,Jiang, Yaxin.,Wang, Qiang.,Ma, Xinyong.,Xiao, Zeyu.,...&Chen, Guang.(2009).Single-molecule imaging reveals transforming growth factor-beta-induced type II receptor dimerization.PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,106(37),15679-15683.
MLA Zhang, Wei,et al."Single-molecule imaging reveals transforming growth factor-beta-induced type II receptor dimerization".PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 106.37(2009):15679-15683.
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