ICCAS OpenIR
Conjugated Polymer/Porphyrin Complexes for Efficient Energy Transfer and Improving Light-Activated Antibacterial Activity
Xing, Chengfen; Xu, Qingling; Tang, Hongwei; Liu, Libing; Wang, Shu
2009-09-16
Source PublicationJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
ISSN0002-7863
Volume131Issue:36Pages:13117-13124
AbstractWith the increasing antibiotic resistance of microorganisms, there is a growing interest in the design and development of new materials that are effective in killing bacteria to replace conventional antibiotics. Herein, a new anionic water-soluble polythiophene (PTP) and a cationic porphyrin (TPPN) are synthesized and characterized. They can forma complex through electrostatic interactions, and efficient energy transfer from PTP to TPPN occurs upon irradiation under white light (400-800 nm). The energy of TPPN transfers to triplet by intersystem crossing, followed by sensitization of oxygen molecule to enhance the efficiency of singlet oxygen generation related to TPPN itself. The positive charges of PTP/TPPN complex promote its adsorption to the negatively charged bacteria membranes of Gram-negative Escherichia coli and Gram-positive Bacillus subtilis through electrostatic interactions, and the singlet oxygen effectively kills the bacteria. The photosensitized inactivation of bacteria for the PTP/TPPN complex is efficient, and about 70% reduction of bacterial viability is observed after only 5 min of irradiation with white light at a fluence rate of 90 mW.cm(-2) (27 J.cm(-2)). The technique provides a promising application in photodynamic inactivation of bacteria on the basis of enhanced energy transfer offered by light-harvesting conjugated polymers.
DOI10.1021/ja904492x
Indexed BySCI ; IC
Language英语
WOS IDWOS:000269736000051
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:194[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/66860
Collection中国科学院化学研究所
Corresponding AuthorLiu, Libing
AffiliationChinese Acad Sci, Beijing Natl Lab Mol Sci, Key Lab Organ Solids, Inst Chem, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Xing, Chengfen,Xu, Qingling,Tang, Hongwei,et al. Conjugated Polymer/Porphyrin Complexes for Efficient Energy Transfer and Improving Light-Activated Antibacterial Activity[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2009,131(36):13117-13124.
APA Xing, Chengfen,Xu, Qingling,Tang, Hongwei,Liu, Libing,&Wang, Shu.(2009).Conjugated Polymer/Porphyrin Complexes for Efficient Energy Transfer and Improving Light-Activated Antibacterial Activity.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,131(36),13117-13124.
MLA Xing, Chengfen,et al."Conjugated Polymer/Porphyrin Complexes for Efficient Energy Transfer and Improving Light-Activated Antibacterial Activity".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 131.36(2009):13117-13124.
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