ICCAS OpenIR
Flavin-sensitized Photo-oxidation of Lysozyme and Serum Albumin
Zhang, Yazhou1,2; Goerner, Helmut1
2009-07-01
Source PublicationPHOTOCHEMISTRY AND PHOTOBIOLOGY
ISSN0031-8655
Volume85Issue:4Pages:943-948
AbstractThe excited state processes of riboflavin, flavin mononucleotide and flavin adenine dinucleotide in argon-saturated aqueous solution were studied in the presence of lysozyme or bovine serum albumin (BSA). UV-Vis absorption and fluorescence spectroscopy indicates that the noncovalent flavin-protein binding is relatively weak. Quenching of the flavin triplet state by BSA, observed by time-resolved photolysis, is less efficient than by lysozyme. Light-induced oxidation of the two proteins and reduction of the three flavins were studied. The quantum yields of the former and latter in the absence of oxygen are up to 0.1 and 0.04, respectively. The effects of pH and sensitizer and protein concentrations were examined in greater detail. The proposed reaction is electron transfer from the tryptophan moiety to the flavin triplet rather than excited singlet state.
DOI10.1111/j.1751-1097.2009.00547.x
Indexed BySCI
Language英语
WOS IDWOS:000267284300013
PublisherWILEY-BLACKWELL PUBLISHING, INC
Citation statistics
Cited Times:14[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/66858
Collection中国科学院化学研究所
Corresponding AuthorGoerner, Helmut
Affiliation1.Max Planck Inst Bioanorgan Chem, Mulheim, Germany
2.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Zhang, Yazhou,Goerner, Helmut. Flavin-sensitized Photo-oxidation of Lysozyme and Serum Albumin[J]. PHOTOCHEMISTRY AND PHOTOBIOLOGY,2009,85(4):943-948.
APA Zhang, Yazhou,&Goerner, Helmut.(2009).Flavin-sensitized Photo-oxidation of Lysozyme and Serum Albumin.PHOTOCHEMISTRY AND PHOTOBIOLOGY,85(4),943-948.
MLA Zhang, Yazhou,et al."Flavin-sensitized Photo-oxidation of Lysozyme and Serum Albumin".PHOTOCHEMISTRY AND PHOTOBIOLOGY 85.4(2009):943-948.
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