ICCAS OpenIR
Antiplatelet and Thermally Responsive Poly(N-isopropylacrylamide) Surface with Nanoscale Topography
Chen, Li2,3; Liu, Mingjie1,3; Bai, Hao1,3; Chen, Peipei1,3; Xia, Fan2,3; Han, Dong1; Jiang, Lei2
2009-08-05
Source PublicationJOURNAL OF THE AMERICAN CHEMICAL SOCIETY
ISSN0002-7863
Volume131Issue:30Pages:10467-10472
AbstractNanoscale topography was constructed on a thermally responsive poly(N-isopropylacrylamide) (PNIPAAm) surface by grafting the polymer from silicon nanowire arrays via surface-initiated atom transfer radical polymerization. The as-prepared surface showed largely reduced platelet adhesion in vitro both below and above the lower critical solution temperature (LCST) of PNIPAAm (similar to 32 degrees C), while a smooth PNIPAAm surface exhibited antiadhesion to platelets only below the LCST. Contact angle and adhesive force measurements on oil droplets (1,2-dichloroethane) in water demonstrated that the nanoscale topography kept a relatively high ratio of water content on the as-prepared-surface and played a key role in largely reducing the adhesion of platelets; however, this effect did not exist on the smooth PNIPAAm surface. The results can be used to extend the applications of PNIPAAm in the fields of biomaterials and biomedicine under human physiological temperature and provide a new strategy for fabricating other blood-compatible materials.
DOI10.1021/ja9019935
Indexed BySCI
Language英语
WOS IDWOS:000268644400041
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:158[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/66734
Collection中国科学院化学研究所
Corresponding AuthorHan, Dong
Affiliation1.Natl Ctr NanoSci & Technol, Beijing 100190, Peoples R China
2.Chinese Acad Sci, BNLMS, Ctr Mol Sci, Inst Chem, Beijing 100190, Peoples R China
3.Chinese Acad Sci, Grad Univ, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Chen, Li,Liu, Mingjie,Bai, Hao,et al. Antiplatelet and Thermally Responsive Poly(N-isopropylacrylamide) Surface with Nanoscale Topography[J]. JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,2009,131(30):10467-10472.
APA Chen, Li.,Liu, Mingjie.,Bai, Hao.,Chen, Peipei.,Xia, Fan.,...&Jiang, Lei.(2009).Antiplatelet and Thermally Responsive Poly(N-isopropylacrylamide) Surface with Nanoscale Topography.JOURNAL OF THE AMERICAN CHEMICAL SOCIETY,131(30),10467-10472.
MLA Chen, Li,et al."Antiplatelet and Thermally Responsive Poly(N-isopropylacrylamide) Surface with Nanoscale Topography".JOURNAL OF THE AMERICAN CHEMICAL SOCIETY 131.30(2009):10467-10472.
Files in This Item:
There are no files associated with this item.
Related Services
Recommend this item
Bookmark
Usage statistics
Export to Endnote
Google Scholar
Similar articles in Google Scholar
[Chen, Li]'s Articles
[Liu, Mingjie]'s Articles
[Bai, Hao]'s Articles
Baidu academic
Similar articles in Baidu academic
[Chen, Li]'s Articles
[Liu, Mingjie]'s Articles
[Bai, Hao]'s Articles
Bing Scholar
Similar articles in Bing Scholar
[Chen, Li]'s Articles
[Liu, Mingjie]'s Articles
[Bai, Hao]'s Articles
Terms of Use
No data!
Social Bookmark/Share
All comments (0)
No comment.
 

Items in the repository are protected by copyright, with all rights reserved, unless otherwise indicated.