ICCAS OpenIR
Facile Preparation of a New Gadofullerene-Based Magnetic Resonance Imaging Contrast Agent with High H-1 Relaxivity
Shu, Chunying3; Corwin, Frank D.1; Zhang, Jianfei3; Chen, Zhijian2; Reid, Jonathan E.3; Sun, Minghao1; Xu, Wei4; Sim, Jae Hyun3; Wang, Chunru4; Fatouros, Panos P.1; Esker, Alan R.3; Gibson, Harry W.3; Dorn, Harry C.3
2009-06-01
Source PublicationBIOCONJUGATE CHEMISTRY
ISSN1043-1802
Volume20Issue:6Pages:1186-1193
AbstractA new magnetic resonance imaging (MRI) contrast agent based on the trimetallic nitride templated (TNT) metallofullerene Gd3N@C-80 was synthesized by a facile method in high yield. The observed longitudinal and transverse relaxivities r(1) and r(2) for water hydrogens in the presence of the water-soluble gadofullerene 2 Gd3N@C-80(OH)(similar to 26)(CH2CH2COOM)(similar to 16) (M = Na or H) are 207 and 282 mM(-1) s(-1) (per C-80 cage) at 2.4 T, respectively; these values are 50 times larger than those of Gd3+ poly(aminocarboxylate) complexes, such as commercial Omniscan and Magnevist. This high H-1 relaxivity for this new hydroxylated and carboxylated gadofullerene derivative provides high signal enhancement at significantly lower Gd concentration as demonstrated by in vitro and in vivo MRI studies. Dynamic light scattering data reveal a unimodal size distribution with an average hydrodynamic radius of ca. 78 nm in pure water (pH = 7), which is significantly different from other hydroxylated or carboxylated. fullerene and metallofullerene derivatives reported to date. Agarose gel infusion results indicate that the gadofullerene 2 displayed diffusion properties different from those of commercial Omniscan and those of PEG5000 modified Gd3N@C-80. The reactive carboxyl functionality present on this highly efficient contrast agent may also serve as a precursor for biomarker tissue-targeting purposes.
DOI10.1021/bc900051d
Indexed BySCI
Language英语
WOS IDWOS:000267117600013
PublisherAMER CHEMICAL SOC
Citation statistics
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/66640
Collection中国科学院化学研究所
Corresponding AuthorFatouros, Panos P.
Affiliation1.Virginia Commonwealth Univ, Dept Radiol, Richmond, VA 23298 USA
2.Virginia Commonwealth Univ, Dept Neurosurg, Richmond, VA 23298 USA
3.Virginia Polytech Inst & State Univ, Dept Chem, Blacksburg, VA 24061 USA
4.Chinese Acad Sci, Inst Chem, Beijing 100080, Peoples R China
Recommended Citation
GB/T 7714
Shu, Chunying,Corwin, Frank D.,Zhang, Jianfei,et al. Facile Preparation of a New Gadofullerene-Based Magnetic Resonance Imaging Contrast Agent with High H-1 Relaxivity[J]. BIOCONJUGATE CHEMISTRY,2009,20(6):1186-1193.
APA Shu, Chunying.,Corwin, Frank D..,Zhang, Jianfei.,Chen, Zhijian.,Reid, Jonathan E..,...&Dorn, Harry C..(2009).Facile Preparation of a New Gadofullerene-Based Magnetic Resonance Imaging Contrast Agent with High H-1 Relaxivity.BIOCONJUGATE CHEMISTRY,20(6),1186-1193.
MLA Shu, Chunying,et al."Facile Preparation of a New Gadofullerene-Based Magnetic Resonance Imaging Contrast Agent with High H-1 Relaxivity".BIOCONJUGATE CHEMISTRY 20.6(2009):1186-1193.
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