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Synthesis of Amphiphilic Biodegradable Glycocopolymers Based on Poly(epsilon-caprolactone) by Ring-Opening Polymerization and Click Chemistry
Xu, Ning; Wang, Rui; Du, Fu-Sheng; Li, Zi-Chen
2009-07-15
Source PublicationJOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY
ISSN0887-624X
Volume47Issue:14Pages:3583-3594
AbstractAmphiphilic, biodegradable block glycopolymers based oil poly(epsilon-caprolactone) (PCL) with various pendent saccharides were synthesized by combination of ring-opening polymerization (ROP) and "click" chemistry. PCL macroinitiators obtained by ROP of epsilon-caprolactone were used to initiate the ROP of 2-bromo-epsilon-caprolactone (BrCL) to get diblock copolymers, PCL-b-PBrCL. Reaction of the block copolymers with sodium azide converted the bromine groups in the PBrCL block to azide groups. In the final step, click chemistry of alkynyl saccharides with the pendent azide groups of PCL-b-PBrCL led to the formation of the amphiphilic block glycopolymers. These copolymers were characterized by (1)H NMR spectroscopy and gel permeation chromatography. The self-assembly behavior of the amphiphilic block copolymers was investigated using transmission electron microscopy and atomic force microscope, spherical aggregates with saccharide groups on the surface were observed, and the aggregates could bind reversibly with Concanavalin A. (C) 2009 Wiley Periodicals, Inc. J Polym Sci Part A: Polym Chem 47: 3583-3594, 2009
KeywordAmphiphilic Biodegradable Block Copolymers "click" Chemistry Glycopolymer Polyesters
DOI10.1002/pola.23443
Indexed BySCI
Language英语
WOS IDWOS:000267444200010
PublisherJOHN WILEY & SONS INC
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Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/66602
Collection中国科学院化学研究所
Corresponding AuthorLi, Zi-Chen
AffiliationPeking Univ, Coll Chem & Mol Engn, BNLMS,Minist Educ, Key Lab Polymer Chem & Phys, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Xu, Ning,Wang, Rui,Du, Fu-Sheng,et al. Synthesis of Amphiphilic Biodegradable Glycocopolymers Based on Poly(epsilon-caprolactone) by Ring-Opening Polymerization and Click Chemistry[J]. JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,2009,47(14):3583-3594.
APA Xu, Ning,Wang, Rui,Du, Fu-Sheng,&Li, Zi-Chen.(2009).Synthesis of Amphiphilic Biodegradable Glycocopolymers Based on Poly(epsilon-caprolactone) by Ring-Opening Polymerization and Click Chemistry.JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY,47(14),3583-3594.
MLA Xu, Ning,et al."Synthesis of Amphiphilic Biodegradable Glycocopolymers Based on Poly(epsilon-caprolactone) by Ring-Opening Polymerization and Click Chemistry".JOURNAL OF POLYMER SCIENCE PART A-POLYMER CHEMISTRY 47.14(2009):3583-3594.
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