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Preparation, Surface Properties and Biological Activity of the Composite of Poly (lactide-co-glycolide) and Bioglass Nanoparticles Surface Grafted with Poly(L-lactide)
Dong Shu-Jun1,2; Yu Ting2; Wei Jun-Chao2; Jing Xia-Bin2; Zhou Yan-Min1; Zhang Pei-Biao2; Chen Xue-Si2
2009-05-10
Source PublicationCHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
ISSN0251-0790
Volume30Issue:5Pages:1018-1023
AbstractSiO(2)-CaO-P(2)O(5) gel bioglass (BG) nanoparticles with the diameter of 40 nm were synthesized by sol-gel approach. The surface of BG nanoparticles was grafted through the ring-open polymerization of the L-lactide to yield poly (L-lactide) (PLLA) grafted gel particle (PLLA-g-BG). The PLLA-g-BG was further blended with poly(lactide-co-glycolide) (PLGA) to prepare the nanocomposites of PLLA-g-BG/PLGA with the various blend ratios of two phases. PLLA-g-BG accounted 10%, 20% and 40% in the composite, respectively. TGA, ESEM and EDX were used to analyze the graft ratio of PLLA-g-BG, the dispersion of nano-particles and the surface elements of the composites respectively. The rabbit osteoblasts were seeded and cultured on the thin films of composites in vitro. The cell adhesion, spreading and growth of osteoblasts were analyzed with FITC staining, NIH Image J software and MTT assay. The change of cell cycle was monitored by flow cytometry (FCM). The results demonstrated that the Surface modification of BG with PLLA could significantly improve the dispersing of the particles in the matrix of PLGA. The nanocomposite with 20% PLLA-g-BG exhibited superior surface properties, including roughness and plenty of silicon, calcium and phosper, to enhance the adhesion, spreading and proliferation of osteoblasts. Our results indicate that the application of PLLA-g-BG with a certain blend ratio can improve the bioactivity and biocompatibility of biodegradable polyester.
KeywordBioglass Nanoparticle Surface Grafting Poly(Lactide-co-glycolide) (Plga) Nanocomposite Bioactivity
Indexed BySCI
Language英语
WOS IDWOS:000266417200035
PublisherHIGHER EDUCATION PRESS
Citation statistics
Cited Times:6[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/66526
Collection中国科学院化学研究所
Corresponding AuthorZhang Pei-Biao
Affiliation1.Jilin Univ, Stomatol Sch, Changchun 130041, Peoples R China
2.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
Recommended Citation
GB/T 7714
Dong Shu-Jun,Yu Ting,Wei Jun-Chao,et al. Preparation, Surface Properties and Biological Activity of the Composite of Poly (lactide-co-glycolide) and Bioglass Nanoparticles Surface Grafted with Poly(L-lactide)[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2009,30(5):1018-1023.
APA Dong Shu-Jun.,Yu Ting.,Wei Jun-Chao.,Jing Xia-Bin.,Zhou Yan-Min.,...&Chen Xue-Si.(2009).Preparation, Surface Properties and Biological Activity of the Composite of Poly (lactide-co-glycolide) and Bioglass Nanoparticles Surface Grafted with Poly(L-lactide).CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,30(5),1018-1023.
MLA Dong Shu-Jun,et al."Preparation, Surface Properties and Biological Activity of the Composite of Poly (lactide-co-glycolide) and Bioglass Nanoparticles Surface Grafted with Poly(L-lactide)".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 30.5(2009):1018-1023.
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