ICCAS OpenIR
Electrospinning of multicomponent ultrathin fibrous nonwovens for semi-occlusive wound dressings
Hong, Youliang1; Li, Yanan2; Zhuang, Xiuli1; Chen, Xuesi1; Jing, Xiabin1
2009-05-01
Source PublicationJOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
ISSN1549-3296
Volume89AIssue:2Pages:345-354
AbstractThis work describes the design and assembly of multifunctional and cost-efficient composite fiber nonwovens as semi-occlusive wound dressings using a simple electrospinning process to incorporate a variety Of functional components into an Ultrathin fiber. These components include non-hydrophilic poly(L-lactide) (PLLA) as fibrous backbone, hydrophilic poly(vinyl pyrrolidone)iodine (PVP-I), TiO(2) nanoparticles, zinc chloride as antimicrobial, odor-controlling, and antiphlogistic agents, respectively. The process of synthesis starts with a multicomponent solution Of PLLA, PVP, TiO(2) nanoparticles plus zinc chloride, in which TiO(2) nanoparticles are synthesized by in situ hydrolysis of TiO(2) precursors in a PVP Solution for the sake of obtaining the particle-uniformly dispersive solution. Subsequent electrospinning generates the corresponding composite fibers. A further iodine vapor treatment to the composite fibers combines iodine with PVP to produce the PVP-I complexes. Experiments indicate that the assembled composite fibers (300-400 nm) possess the ointment-releasing characteristic and the phase-separate, core-sheath structures in which PVP-I residing in fiber Surface layer becomes the sheath, and PLLA distributing inside the fiber acts as the core. Based on this design, the structural advantages combining active components endow the assembled composite nonwovens with a variety of functions, especially, the existence of PVP-I, endows the nonwoven with water absorbability, antimicrobial activity, adhesive ability, and transformable characteristic from hydrophilicity to non-hydrophilicity. The multifunctional, cost-efficient, and ointment-releasing characteristics make the multicomponent composite fibrous nonwovens potentially useful in applications such as initial stage of dressing of the cankerous or contaminated wounds. (C) 2008 Wiley Periodicals, Inc. J Biomed Mater Res 89A: 345-354, 2009
KeywordElectrospinning Multicomponent Ultrathin Fibers Antibacterial Ointment-releasing Nonwoven Semi-occlusive Wound Dressing
DOI10.1002/jbm.a.31968
Indexed BySCI
Language英语
WOS IDWOS:000264850200007
PublisherWILEY-LISS
Citation statistics
Cited Times:20[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/66486
Collection中国科学院化学研究所
Corresponding AuthorChen, Xuesi
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Jilin Univ, Hosp 1, Dept Pharm, Changchun 130012, Peoples R China
Recommended Citation
GB/T 7714
Hong, Youliang,Li, Yanan,Zhuang, Xiuli,et al. Electrospinning of multicomponent ultrathin fibrous nonwovens for semi-occlusive wound dressings[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2009,89A(2):345-354.
APA Hong, Youliang,Li, Yanan,Zhuang, Xiuli,Chen, Xuesi,&Jing, Xiabin.(2009).Electrospinning of multicomponent ultrathin fibrous nonwovens for semi-occlusive wound dressings.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,89A(2),345-354.
MLA Hong, Youliang,et al."Electrospinning of multicomponent ultrathin fibrous nonwovens for semi-occlusive wound dressings".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 89A.2(2009):345-354.
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