ICCAS OpenIR
Core Crosslinking of Biodegradable Block Copolymer Micelles Based on Poly(ester carbonate)
Hu, Xiuli1,2; Chen, Xuesi1; Wei, Jizheng1,2; Liu, Shi1; Jing, Xiabin1
2009-05-13
Source PublicationMACROMOLECULAR BIOSCIENCE
ISSN1616-5187
Volume9Issue:5Pages:456-463
AbstractA biodegradable amphiphilic block copolymer, PEG-b-P(LA-co-MAC), was used to prepare spherical micelles consisting of a hydrophobic P(LA-co-MAC) core and a hydrophilic PEG shell. To improve their stability, the micelles were crosslinked by radical polymerization of the double bonds in the hydrophobic blocks. The crosslinked micelles had similar sizes and a narrow size distribution compared to their uncrosslinked precursor. The improved stability of the crosslinked micelles was confirmed by measurements of the CMC and a thermodynamic investigation. These micelles can internalize into Hela cells in vitro as demonstrated by inverted fluorescence microscopy and CLSM. These stabilized nanoscale micelles have potential use in biomedical applications such as drug delivery and disease diagnosis.
KeywordBiodegradable Core Crosslinking Drug Delivery Systems Polycarbonates Self-assembly
DOI10.1002/mabi.200800158
Indexed BySCI
Language英语
WOS IDWOS:000266456200007
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:38[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/66450
Collection中国科学院化学研究所
Corresponding AuthorJing, Xiabin
Affiliation1.Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Hu, Xiuli,Chen, Xuesi,Wei, Jizheng,et al. Core Crosslinking of Biodegradable Block Copolymer Micelles Based on Poly(ester carbonate)[J]. MACROMOLECULAR BIOSCIENCE,2009,9(5):456-463.
APA Hu, Xiuli,Chen, Xuesi,Wei, Jizheng,Liu, Shi,&Jing, Xiabin.(2009).Core Crosslinking of Biodegradable Block Copolymer Micelles Based on Poly(ester carbonate).MACROMOLECULAR BIOSCIENCE,9(5),456-463.
MLA Hu, Xiuli,et al."Core Crosslinking of Biodegradable Block Copolymer Micelles Based on Poly(ester carbonate)".MACROMOLECULAR BIOSCIENCE 9.5(2009):456-463.
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