ICCAS OpenIR
A Novel Type of Dual-Modality Molecular Probe for MR and Nuclear Imaging of Tumor: Preparation, Characterization and in Vivo Application
Liu, Shujie1; Jia, Bing2; Qiao, Ruirui1; Yang, Zhi4; Yu, Zilin2; Liu, Zhaofei2; Liu, Kan3; Shi, Jiyun2; Han Ouyang3; Wang, Fan2; Gao, Mingyuan1
2009-07-01
Source PublicationMOLECULAR PHARMACEUTICS
ISSN1543-8384
Volume6Issue:4Pages:1074-1082
AbstractA novel dual-modality molecular probe composed of biocompatible Fe3O4 nanocrystal, monoclonal antibody and radionuclide was designed and prepared. All functional components in the dual-modality molecular probe, i.e., Fe3O4, PEG, mAb 3H11 and 12 I-125, were chemically bonded together for forming a stable molecular probe. Systematic in vitro experiments were carried out for evaluating the biological activity of the antibody in the targeting probe. A series of in vivo experiments were performed based on the dual-modality imaging probe for detecting xenografted tumors in nude mice by MRI and gamma-imaging techniques. The pharmacokinetics of the dual-modality molecular probe in tumor-bearing nude mice was studied.
KeywordDual-modality Molecular Probe Mri Nuclear Imaging Fe3o4 Nanocrystals Tumor
DOI10.1021/mp900143a
Indexed BySCI
Language英语
WOS IDWOS:000268456300004
PublisherAMER CHEMICAL SOC
Citation statistics
Cited Times:61[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/66326
Collection中国科学院化学研究所
Corresponding AuthorGao, Mingyuan
Affiliation1.Chinese Acad Sci, Inst Chem, Beijing 100190, Peoples R China
2.Peking Univ, Med Isotopes Res Ctr, Beijing 100191, Peoples R China
3.Chinese Acad Med Sci, Canc Hosp, Beijing 100021, Peoples R China
4.Peking Univ, Oncol Sch, Beijing 100036, Peoples R China
Recommended Citation
GB/T 7714
Liu, Shujie,Jia, Bing,Qiao, Ruirui,et al. A Novel Type of Dual-Modality Molecular Probe for MR and Nuclear Imaging of Tumor: Preparation, Characterization and in Vivo Application[J]. MOLECULAR PHARMACEUTICS,2009,6(4):1074-1082.
APA Liu, Shujie.,Jia, Bing.,Qiao, Ruirui.,Yang, Zhi.,Yu, Zilin.,...&Gao, Mingyuan.(2009).A Novel Type of Dual-Modality Molecular Probe for MR and Nuclear Imaging of Tumor: Preparation, Characterization and in Vivo Application.MOLECULAR PHARMACEUTICS,6(4),1074-1082.
MLA Liu, Shujie,et al."A Novel Type of Dual-Modality Molecular Probe for MR and Nuclear Imaging of Tumor: Preparation, Characterization and in Vivo Application".MOLECULAR PHARMACEUTICS 6.4(2009):1074-1082.
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