ICCAS OpenIR
Synthesis and biological evaluation of radioiodinated 2NUBTA as a cerebral ischemia marker
Chu, Taiwei; Li, Zejun; Wang, Xiangyun
2009-02-01
Source PublicationBIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN0960-894X
Volume19Issue:3Pages:658-661
AbstractN-[4-(Benzothiazol-2-yl) phenyl]-11-(2-nitroimidazole-1-yl) undecanamide (2NUBTA) was synthesized and radiolabeled with iodine-131. In vitro evaluation of the [(131)I] 2NUBTA using murine sarcoma S180 cells showed increase in radioactivity in hypoxic cells up to 4 h, while it was not in aerobic cells. Its potential as a cerebral ischemia marker was evaluated using gerbil stroke models that had been subjected to right common carotid artery ligation to produce cerebral ischemia. The uptake in the right cerebral hemisphere decreased slowly than that of the left and the right/left hemisphere uptake ratios increased with time going on. It indicated that [(131)I]2NUBTA might be a possible cerebral ischemia marker. (c) 2008 Elsevier Ltd. All rights reserved.
KeywordCerebral Ischemia Marker Radiolabeling Hypoxia Lipophilicity Intact Blood-brain Barrier 2-nitroimidazole Thioflaven-t
DOI10.1016/j.bmcl.2008.12.052
Indexed BySCI
Language英语
WOS IDWOS:000262707000016
PublisherPERGAMON-ELSEVIER SCIENCE LTD
Citation statistics
Cited Times:4[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/66312
Collection中国科学院化学研究所
Corresponding AuthorChu, Taiwei
AffiliationPeking Univ, Coll Chem & Mol Engn, Dept Appl Chem, BNLMS, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Chu, Taiwei,Li, Zejun,Wang, Xiangyun. Synthesis and biological evaluation of radioiodinated 2NUBTA as a cerebral ischemia marker[J]. BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,2009,19(3):658-661.
APA Chu, Taiwei,Li, Zejun,&Wang, Xiangyun.(2009).Synthesis and biological evaluation of radioiodinated 2NUBTA as a cerebral ischemia marker.BIOORGANIC & MEDICINAL CHEMISTRY LETTERS,19(3),658-661.
MLA Chu, Taiwei,et al."Synthesis and biological evaluation of radioiodinated 2NUBTA as a cerebral ischemia marker".BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19.3(2009):658-661.
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