ICCAS OpenIR
Folate-Conjugated Micelles and Their Folate-Receptor-Mediated Endocytosis
Lu, Tiancheng1,2,3; Sun, Jing1,3; Chen, Xuexi1; Zhang, Peibiao1; Jing, Xiabin1
2009-11-10
Source PublicationMACROMOLECULAR BIOSCIENCE
ISSN1616-5187
Volume9Issue:11Pages:1059-1068
AbstractA folate-conjugated copolymer PEG-PLA-PLL/folate was synthesized and mixed with pure PEG-PLA-PLL and a fluorescent model drug mFITC to prepare folate-conjugated micelles. The distribution of micelles was studied on cancer-cell-bearing mice via frozen slicing. The results show that mFITC is successfully encapsulated into folate(+) and folate(-)micelles; PEG-PLA-PLL micelles the latter can be internalized by both HeLa and CHO cells without selectivity due to their cationic surface charges, while folate(+)micelles exhibit more preferential endocytosis by HeLa cells than by CHO cells. The folate(-)micelles showed retention in both organs and tumors. The folate(+)micelles are a promising active targeting drug delivery system for FR over-expressing cells and they accumulate in tumor beds.
KeywordEndocytosis Folic Acid Micelles Receptor Targeting
DOI10.1002/mabi.200900134
Indexed BySCI
Language英语
WOS IDWOS:000271990000002
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:45[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/66302
Collection中国科学院化学研究所
Corresponding AuthorJing, Xiabin
Affiliation1.Chinese Acad Sci, State Key Lab Polymer Phys & Chem, Changchun Inst Appl Chem, Changchun 130022, Peoples R China
2.Jilin Agr Univ, Sch Life Sci, Changchun 130118, Peoples R China
3.Chinese Acad Sci, Grad Sch, Beijing 100039, Peoples R China
Recommended Citation
GB/T 7714
Lu, Tiancheng,Sun, Jing,Chen, Xuexi,et al. Folate-Conjugated Micelles and Their Folate-Receptor-Mediated Endocytosis[J]. MACROMOLECULAR BIOSCIENCE,2009,9(11):1059-1068.
APA Lu, Tiancheng,Sun, Jing,Chen, Xuexi,Zhang, Peibiao,&Jing, Xiabin.(2009).Folate-Conjugated Micelles and Their Folate-Receptor-Mediated Endocytosis.MACROMOLECULAR BIOSCIENCE,9(11),1059-1068.
MLA Lu, Tiancheng,et al."Folate-Conjugated Micelles and Their Folate-Receptor-Mediated Endocytosis".MACROMOLECULAR BIOSCIENCE 9.11(2009):1059-1068.
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