ICCAS OpenIR
The Influence of Pendant Hydroxyl Groups on Enzymatic Degradation and Drug Delivery of Amphiphilic Poly[glycidol-block-(epsilon-caprolactone)] Copolymers
Mao, Jing1,2; Gan, Zhihua1
2009-11-10
Source PublicationMACROMOLECULAR BIOSCIENCE
ISSN1616-5187
Volume9Issue:11Pages:1080-1089
AbstractAn amphiphilic diblock copolymer PG-b-PCL with well-controlled structure and pendant hydroxyl groups along hydrophilic block was synthesized by sequential anionic ring-opening polymerization. The micellization and drug release of PG-b-PCL copolymers using pyrene as a fluorescence probe were investigated for determining the influences of copolymer composition and lipase concentration on drug loading capacity and controlled release behavior. The biodegradation of PG-b-PCL copolymers was studied with microspheres as research samples. It has been concluded that the polar hydroxyl groups along each repeat unit of hydrophilic PG block in PG-b-PCL copolymer have great influences on drug encapsulation, drug release, and enzymatic degradation of micelles and microspheres.
KeywordBlock Copolymers Controlled Polymerization Drug Delivery Enzymatic Degradation Micelles
DOI10.1002/mabi.200900104
Indexed BySCI
Language英语
WOS IDWOS:000271990000004
PublisherWILEY-V C H VERLAG GMBH
Citation statistics
Cited Times:18[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/66232
Collection中国科学院化学研究所
Corresponding AuthorGan, Zhihua
Affiliation1.Chinese Acad Sci, CAS Key Lab Engn Plast, Inst Chem, Beijing 100190, Peoples R China
2.Chinese Acad Sci, Grad Sch, Beijing 100049, Peoples R China
Recommended Citation
GB/T 7714
Mao, Jing,Gan, Zhihua. The Influence of Pendant Hydroxyl Groups on Enzymatic Degradation and Drug Delivery of Amphiphilic Poly[glycidol-block-(epsilon-caprolactone)] Copolymers[J]. MACROMOLECULAR BIOSCIENCE,2009,9(11):1080-1089.
APA Mao, Jing,&Gan, Zhihua.(2009).The Influence of Pendant Hydroxyl Groups on Enzymatic Degradation and Drug Delivery of Amphiphilic Poly[glycidol-block-(epsilon-caprolactone)] Copolymers.MACROMOLECULAR BIOSCIENCE,9(11),1080-1089.
MLA Mao, Jing,et al."The Influence of Pendant Hydroxyl Groups on Enzymatic Degradation and Drug Delivery of Amphiphilic Poly[glycidol-block-(epsilon-caprolactone)] Copolymers".MACROMOLECULAR BIOSCIENCE 9.11(2009):1080-1089.
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