Clickable fluorophores for biological labeling-with or without copper
Kele, Peter1,2; Li, Xiaohua2,3; Link, Martin2; Nagy, Krisztina1; Herner, Andras1; Lorincz, Krisztian1; Beni, Szabolcs4; Wolfbeis, Otto S.2
AbstractThe synthesis of a set of new clickable fluorophores that virtually cover the whole visible spectrum reaching the near infra-red regime is presented herein. Besides dyes that are capable of participating in classical copper catalyzed 1,3-dipolar cycloaddition reactions with the counterparting function we have also prepared dyes containing a cyclooctyne moiety, an alkyne derivative that enables copper free clicking to azides. The suitability of these dyes for fluorescent labeling of biomolecules is presented by examples on model frameworks representing major biopolymer building blocks. The versatility of these dyes is presented in cell labeling experiments as well as by labeling the azide modified surface glycans of CHO-cells either by copper catalyzed or copper-free click reaction. These dyes are expected to have a large variety of applications in (bio)orthogonal labeling schemes both in vivo and in vitro.
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WOS IDWOS:000268975300019
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Cited Times:57[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Corresponding AuthorKele, Peter
Affiliation1.Eotvos Lorand Univ, Inst Chem, H-1117 Budapest, Hungary
2.Univ Regensburg, Inst Analyt Chem Chemo & Biosensors, D-93040 Regensburg, Germany
3.Chinese Acad Sci, Inst Chem, Beijing Natl Lab Mol Sci, Beijing 100190, Peoples R China
4.Semmelweis Univ, HAS Res Grp Drugs Abuse, Dept Pharmaceut Chem, H-1092 Budapest, Hungary
Recommended Citation
GB/T 7714
Kele, Peter,Li, Xiaohua,Link, Martin,et al. Clickable fluorophores for biological labeling-with or without copper[J]. ORGANIC & BIOMOLECULAR CHEMISTRY,2009,7(17):3486-3490.
APA Kele, Peter.,Li, Xiaohua.,Link, Martin.,Nagy, Krisztina.,Herner, Andras.,...&Wolfbeis, Otto S..(2009).Clickable fluorophores for biological labeling-with or without copper.ORGANIC & BIOMOLECULAR CHEMISTRY,7(17),3486-3490.
MLA Kele, Peter,et al."Clickable fluorophores for biological labeling-with or without copper".ORGANIC & BIOMOLECULAR CHEMISTRY 7.17(2009):3486-3490.
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