ICCAS OpenIR
A novel hypocrellin B derivative designed and synthesized by taking consideration to both drug delivery and biological photodynamic activity
Liu, Xin1; Xie, Jie1; Zhang, Luyong2; Chen, Hongxia2; Gu, Ying2; Zhao, Jingquan1
2009-03-03
Source PublicationJOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
ISSN1011-1344
Volume94Issue:3Pages:171-178
AbstractFor making hypocrellins clinically applicable for phototherapy to vascular diseases, it is mainly focused onto finding a derivative which can be transported fluently in blood system but without serious loss of the inherent activity of its parents. Based on this consideration, a novel 17-3-amino-1-propane-sulfonic acid-HB Schiff-base (NSHB) was designed and synthesized in this work. As expected, NSHB is readily dissolved in phosphate buffered saline (PBS) or any other aqueous solvent in a concentration which is suitable for intravenous injection, while the quite higher partition coefficient (5:1) is beneficial to the affinity to biological targets. Based on EPR measurements, it is proved that the photosensitization activity of NSHB to photo-generate semiquinone anion radicals and superoxide anion radical (O(2)(center dot)) is even higher than its parent HB, while the ability to generate singlet oxygen ((1)O(2)) is not seriously reduced. In addition, nearly comparable PDT activity to A549 cells for NSHB and HB confirms that the molecular design is successful and NSHB is readily delivered into target tissues via blood circulation after intravenous injection. Furthermore, the quantum yield Of (1)O(2) for NSHB is as 12.5 times as that for HB under red light (600-700 nm). which is beneficial to phototherapy to solid tumors. (C) 2008 Elsevier B.V. All rights reserved.
KeywordHypocrellins Epr Spectra Photodynamic Therapy (Pdt) Singlet Oxygen Photosensitization Activity
DOI10.1016/j.jphotobiol.2008.11.008
Indexed BySCI
Language英语
WOS IDWOS:000264225000004
PublisherELSEVIER SCIENCE SA
Citation statistics
Cited Times:16[WOS]   [WOS Record]     [Related Records in WOS]
Document Type期刊论文
Identifierhttp://ir.iccas.ac.cn/handle/121111/66024
Collection中国科学院化学研究所
Corresponding AuthorZhao, Jingquan
Affiliation1.Chinese Acad Sci, Inst Chem, BNLMS, Key Lab Photochem, Beijing 100080, Peoples R China
2.Chinese Peoples Liberat Army Gen Hosp, Dept Laser Med, Beijing 100853, Peoples R China
Recommended Citation
GB/T 7714
Liu, Xin,Xie, Jie,Zhang, Luyong,et al. A novel hypocrellin B derivative designed and synthesized by taking consideration to both drug delivery and biological photodynamic activity[J]. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,2009,94(3):171-178.
APA Liu, Xin,Xie, Jie,Zhang, Luyong,Chen, Hongxia,Gu, Ying,&Zhao, Jingquan.(2009).A novel hypocrellin B derivative designed and synthesized by taking consideration to both drug delivery and biological photodynamic activity.JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY,94(3),171-178.
MLA Liu, Xin,et al."A novel hypocrellin B derivative designed and synthesized by taking consideration to both drug delivery and biological photodynamic activity".JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 94.3(2009):171-178.
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